The present invention provides a VP1 chimera which exploits the self-assembly capacity of VP1 and the potential immunogenicity of exposed loops as a vehicle for delivery for VLP production and vaccine delivery. However, the invention more broadly provides a pharmaceutical composition not limited to use...
“Controlled release microparticles as a single dose diphtheria toxoid vaccine: immunogenicity in small animal models” Vaccine. 16(4):346-352. Yoshimura et al., 2001. “Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with...
In a further preferred form of the present invention the vaccine comprises a water-in-oil formulation. It is further preferred that the vaccine includes at least one antigen to which the individual will mount an anamnestic response in addition to the at least one cytotoxic T-cell epitope. The ...
One example of such a form for administration to a patient in vivo is a live recombinant viral vaccine. Such a vaccine includes a polynucleotide encoding the DEC-205 ligand (or a portion thereof) and the antigen. The vaccine is administered to the patient and, once within the patient, expre...
The method of the invention is applicable to the treatment of any form of inflammatory bowel disease, including but not limited to Crohn's disease (regional bowel disease); ulcerative colitis; autoimmune and immune-mediated diseases of the small and large bowel such as lymphocytic-plasmocytic ente...
the recent concern that young adults (vaccinated during their childhood) with waning immunity against whooping may serve as a reservoir for the pathogen, and thus may be passing it on to their children, have stimulated interest in the development of an alternative vaccine which can also be used...