Quantal dose-responseIn this paper the properties of C-optimal designs constructed for estimating the median effective dose within the framework of two-parametric linear logistic models are critically assessed. It is well known that this design criterion which is based on the first-order variance...
1 Example of benchmark dose (BMD), BMDL in Dose-response curve. A dose-response curve illustrating relationship between BMD10 and BMDL10. Dots: fraction of animals affected in each dose group; Solid curve: Fitted model; BMD10: BMD corresponding to 10% extra risk on this curve based on ...
between 1 nM and 1 μM, a response can be detected, but the antigen dose-response curve is shifted 100–300-fold to the right. In addition, the adaptive phenomenon cannot be ascribed to active suppression by a T-Reg differentiative process, in that the adapted cells do not express CD25...
Home > Section > Chapter Kristofferson, A.B. Annals of the new York Academy of Sciences 423: 3-15 1984 ISSN/ISBN:0077-8923 6588795 10.1111/j.1749-6632.1984.tb23413.x 029014828 Full-Text Article emailed within 0-6 h Payments are secure & encrypted...
Consistently, cocaine failed to increase the extracellular NE levels in the medial prefrontal cortex in these mice (Figure S2D), demonstrating that the NET-CI mice are insensitive to the cocaine dose used by cocaine users. Importantly, the cocaine-induced potentiation effect on [NE] and quantal ...
In consequence, the shape of its associated dose-response curve has no physicochemical bearings; instead, they are originated from random biological variations. Due to the randomness of tolerance there is no reason to use deterministic equations for its analysis; on the contrary, statistical models ...
quantal response curveposterior meaneffective dosedesign measureIt is important in many econometric and biological applications to evaluate the effective dose (ED) points in the tails of quantal response curves and the curves according to a sensible criterion. Following Geisser (1971), it seems most ...
dose-response curvesrelative potency.A general inverse regression procedure for estimating dose-response curves in quanta1 response assays is presented. Asymptotic distributional properties are developed. The special case is given, where after suitable transformation, the -dose response curve is linear. ...
Vågerö, M, Sundberg, R (1999) The distribution of the maximum likelihood estimator in up-and-down experiments for quantal dose-response data. J Biopharmaceut Statist 9: pp. 499-519Vagero M, Sundberg R (1999) The distribution of the maximum likelihood estimator in up-and- down ...
Response curveRiskBayesian methods for estimating dose response curves from linearized multi-stage models in quantal bioassay are studied. A Gibbs sampling approach with data augmentation is employed to compute the Bayes estimates. In addition, estimation of the "relative additional risk" and the "...