Dose-response curveEffective dose 50Monte Carlo studyA kernel method for the estimation of quantal dose-response curves is considered. In contrast to parametric modeling, this local smoothing method does not require any assumptions beyond smoothness of the dose-response curve and, in this sense, is...
In consequence, the shape of its associated dose-response curve has no physicochemical bearings; instead, they are originated from random biological variations. Due to the randomness of tolerance there is no reason to use deterministic equations for its analysis; on the contrary, statistical models ...
Dose-response curve of ATP inhibition of quantal size. (PDF 203 kb) Supplementary Fig. 2 PMA enhances Ca2+-dependent secretion by increasing the number of release events but not quantal size or amperometric spike kinetics. (PDF 484 kb) Supplementary Fig. 3 PMA inhibits digitonin-induced quantal...
We address the question of how to choose the number of doses when estimating the median effective dose (ED50) of a symmetric dose-response curve by the max... HGM Schmitt - 《Biometrics》 被引量: 37发表: 1990年 Methods of estimating the LD 50 in quantal response data A quantal response...
to the completely different mechanisms by which the response is produced in the two cases and that infective particles act in a manner which restricts the steepness of the dose-response curve and consequently restricts the precision with which the ED50 of an infective preparation can be estimated....
We consider quantal dose-response experiments with a binary outcome and develop mu... Z Wei,KW Weng - Institute of Mathematical Statistics 被引量: 49发表: 1998年 A Clinical Experiment in Bone Marrow Transplantation: Estimating a Percentage Point of a Quantal Response Curve A pilot clinical ...
quantal response curveposterior meaneffective dosedesign measureIt is important in many econometric and biological applications to evaluate the effective dose (ED) points in the tails of quantal response curves and the curves according to a sensible criterion. Following Geisser (1971), it seems most ...
Quantal dose-responseIn this paper the properties of C-optimal designs constructed for estimating the median effective dose within the framework of two-parametric linear logistic models are critically assessed. It is well known that this design criterion which is based on the first-order variance...
Dose-response curveModel averagingRisk assessmentSimulationToxicologyBackground: To employ the benchmark dose (BMD) method in toxicological risk assessment, it is critical to understand how the BMD lower bound for reference dose calculation is selected following statistical fitting procedures of multiple ...
dose-response curveinterval estimationbioassayThis paper describes computational methods for applying known theoretical results to obtain confidence bounds for a single location or scale parameter from quantal data using the discrete distribution of either the maximum likelihood or a method of moments ...