Regarding hnRNP’s role in binding RNA G4Qs, hnRNP A1 was shown to be involved in mRNA transport, chaperoning the RNA into the cytoplasm and present near translation (von Hacht et al.2014). This information was determined from pull-down studies using the matrix metalloproteinase MT3-MMP (als...
near the transcription start site at 20% of genes, especially highly transcribed genes. XPB and XPD enrichment at G4 motifs characterizes specific signaling pathways and regulatory pathways associated with specific cancers. These results identify new candidate pathways for therapies targeted to quadruplex...
Reannealing is further inhibited when DNA:RNA hybrids are generated near G4s [109], [118]. Moreover, given the important roles for G4 structures in transcriptional regulation, their resolution outside DNA replication must be tightly controlled. These facts suggest that more complex mechanisms may...
For example, TMPyP4, a tetra-(N-methyl-4-pyridyl)-porphyrin, is a structure-based designed compound that exhibits significant selec- tivity for quadruplex DNA over duplex DNA and inhibits telome- rase and ALT [216, 217]. Its positional isomer TMPyP2 is a poor G-quadruplex-interactive ...