G4 motifs are greatly enriched near promoters, suggesting that quadruplex structures may be targets of transcriptional regulation. Here we show, by ChIP-Seq analysis of human cells, that 40% of the binding sites of the transcription-associated helicases, XPB and XPD, overlap with G4 motifs. Th...
To this date little is known regarding the risks of long-term treatment and how G4 formation is changed over time during treatment and how/if this contributes to tumor relapse. We believe that these questions are of high relevance and that they will be addressed in the near future. Here, ...
It also has a half-life (T1/2) in vivo of 37 h and there is no evidence of hERG or other receptor liabilities at or near therapeutic doses. Its superior activity was also observed in in vivo xenograft and KPC models for PDAC, with significant anti-tumor activity at a once-weekly ...
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