为了搞清楚这中间的奥秘,来自多个研究机构的科研人员齐心协力,在《Cell Genomics》期刊上发表了一篇名为 “Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants” 的论文。他们通过研究发现了 70,446 个影响基因表达和染色质表型的多组学 QTL(Quantitative Trait L...
1 kbp. There could be several reasons to why our QTL study and GWAS gave contrasting results including differences in how associations are modelled (cosegregation in pedigree vs. LD associations), how covariates are accounted for in the models, type of marker used (multi- vs. biallelic), ...
为了搞清楚这中间的奥秘,来自多个研究机构的科研人员齐心协力,在《Cell Genomics》期刊上发表了一篇名为 “Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants” 的论文。他们通过研究发现了 70,446 个影响基因表达和染色质表型的多组学 QTL(Quantitative Trait L...
QTL mapping identifies the significant genetic regions linked to desired traits, while GWASs enhance precision using larger populations. The integration of high-throughput phenotyping has further improved the efficiency and accuracy of QTL research and GWASs, enabling precise trait anal...
Most agricultural traits are controlled by quantitative trait loci (QTLs); however, there are few studies on QTL mapping of horticultural traits in pepper (Capsicum spp.) due to the lack of high-density molecular maps and the sequence information. In this study, an ultra-high-density map and...
由于SNP标记与QTL往往不是完全连锁(r2=1),所以PEVSNP≤PEVQTL。两者的关系是 PEVSNP≈r2 PEVQTL。比如,当SNP与QTL的r2值=0.1的时候,PEVSNP仅仅为PEVQTL的1/10,那么这个SNP检测到的关联信号已经非常微弱了。所以,GWAS分析必须保证有足够的标记密度,保证潜在的QTL一定有足够近...
Hidden covariates with prior (HCP) [33] is another popular hidden variable inference method for QTL mapping. Though less popular than PEER, it has also been used in some high-impact studies [22,23]. To determine which method is the best and whether PEER indeed has the perceived advantages,...
GWAS and genomic selection for marker-assisted development of sucrose enriched soybean cultivars Article 26 August 2023 Genetic analysis of sucrose concentration in soybean seeds using a historical soybean genomic panel Article 03 February 2022 Genetic mapping high protein content QTL from soybean ‘...
通过基因芯片做的SNP标记，然后在QTLlcimapping中，通过map和qtl定位，定位到的点都在一个染色体，而且...
A more detailed analysis of this issue is provided in the meta-analysis vs. privateQTL in eQTL mapping: a comparative analysis section in the STAR Methods. Lastly, we examined whether our hidden covariate correction strategy in privateQTL-II, where each site performs a local PCA on gene ...