Furthermore, QSG significantly decreased the protein levels of P65鈥揘F-魏B, NLRP3, ASC, Caspase-1 (P20), Cleaved IL-18, Cleaved IL-1尾 and NT-GSDMD. This study is the first to demonstrate that QSG has cardioprotective effects by inhibiting inflammasome activation and pyroptosis, which are...
至此,我们发现QSG保护心肌组织免受AMI损伤的药效与NLRP3抑制剂MCC950相同,这表明QSG保护心肌组织免受炎症损伤可能与NLRP3炎症体的抑制有关。 Figure 3 QSG inhibited NLRP3inflamat some activation in cardiac tissue macrophages. 为了直接明确心肌组织中是否存在NLRP3炎症体的激活,采用NLRP3、ASC和Caspase-1三种抗体进...