The meaning of PYRUVATE KINASE is an enzyme that functions in glycolysis by catalyzing especially the transfer of phosphate from phosphoenolpyruvate to ADP forming pyruvate and ATP.
2.4 Pyruvate kinase (PK) Pyruvate kinase (PK) which catalyses the last irreversible step of glycolysis (conversion of phosphoenolpyruvate to pyruvate), consists of four isoforms (PKL, PKR, PKM1 and PKM2) and aberrant expression of PKM2, in particular, is associated with tumorigenesis and chemoresi...
An important question is how the cancer cells coordinate the changes of glycolysis and glutaminolysis. In this report, we demonstrate that the pyruvate kinase inactive dimer PKM2 facilitates activation of glutaminolysis. Our experiments show that growth stimulations promote PKM2 dimer. The dimer PKM2 ...
Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric mechanisms governing PYK activity in bacterial pathogens are poorly understood. Here we report bioc...
Death-associated protein kinase (DAPk), a multi-domain serine/threonine kinase, regulates numerous cell death mechanisms and harbors tumor suppressor functions. In this study, we report that DAPk directly binds and functionally activates pyruvate kinase M2 (PKM2), a key glycolytic enzyme, which contr...
Adiponectin stimulates fatty acid oxidation through activation of AMP-activated protein kinase (AMPK) in myocytes45. Genes encoding key lipid uptake mediators are down-regulated in KSPAKO. In order to analyze the overall effect of renal adiponectin on systemic lipid metabolism, we performed a triglyce...
Pyruvate kinase (PK) is an enzyme that catalyzes the final step in glycolysis, converting phosphoenolpyruvate (PEP) and adenosine diphosphate (ADP) to pyruvate (PYR) and adenosine triphosphate (ATP). There are four mammalian pyruvate kinase isoforms, PKM1, PKM2, PKR, and PKL, and each isoform...
BRAF is part of the MAPK (Mitogen Activated Protein Kinase) signal transduction pathway along with the downstream effectors MEK and ERK, playing a crucial role in cell proliferation, differentiation and apoptosis [2,3,4]. Since the 70′s and the approval of the alkylating agent dacarbazine [4...
A phosphotransferase catalyzing the transfer of phosphate from phosphoenolpyruvate to adenosine diphosphate, forming adenosine triphosphate and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; pyruvate kinase deficiency leads to hemolytic anemia. Medical Dictionar...
showing that oxalic acid inhibits glycolysis at the pyruvate kinase step with an increase of phosphonenolpyruvate, a decrease in lacate and pyruvate production and a reduction of glycolytic flux that will explain its differential efficacy on the A549 cell line [5]. Impact of common organics on ...