Pyruvate Kinase (PK) 英文别名: Pyruvate Kinase (PK) 中文名: 中文别名: CBNumber: CB34670561 分子式: 分子量: 0 MOL File: Mol file Pyruvate Kinase (PK)化学性质 储存条件: 2-8°C 形态: suspension 生物来源: rabbit muscle Specific Activity: ...
Pyruvate Kinase (HRP) CAS号: 英文名: Pyruvate Kinase (HRP) 英文别名: Pyruvate Kinase (HRP) 中文名: 中文别名: CBNumber: CB5987322 分子式: 分子量: 0 MOL File: Mol file Pyruvate Kinase (HRP)化学性质 安全信息 Pyruvate Kinase (HRP)性质、用途与生产工艺 ...
Three analogs of phosphoenolpyruvic acid: (Z)-phosphoenol-3-fluoropyruvate, (Z)-phosphoenol-3-bromopyruvate and (Z)-phosphoenol-伪-ketobutyrate were found to be substrates for yeast pyruvate kinase (ATP : pyruvate (Z)- O-phosphotransferase, EC 2.7.1.40) with maximal velocities much greater ...
In this chapter, molecular properties of pyruvate kinase are described. Enzyme purification, composition, structure, chemical modification, and conformational change are explained. Catalytic properties are also described in the chapter. 展开 DOI: 10.1016/S1874-6047(08)60071-2 被引量: 8 ...
A scheme for the preparation of pyruvate kinase (EC 2.7.1.40) in gram amounts from yeast is described which utilizes two (NH4)2SO4 fractionations followed by successive chromatography on DEAE-cellulose and cellulose phosphate columns in 50% aqueous glycerol. The resulting enzyme had a specific ...
Herein, based on the chemical structure, PKM2 activators are classified into sulfonamide, phenolic, carboxamide and pyridopyrimidinone derivatives. Expert opinion: PKM2 activation inhibits cell growth and proliferation by decreasing a number of biomolecules required for cell building. Therefore; PKM2 ...
During exosome secretion, phosphorylated PKM2 forms a dimer structure with low pyruvate kinase activity but high protein kinase activity21 and then associates with SNAP-23 near cell’s membranes, leading to SNAP-23 phosphorylation at Ser95 and upregulation of tumour cell exosome release. We conclude...
The chemical structure of HsA illustrated in Fig. 1A was already confirmed by nuclear magnetic resonance spectroscopy16. The in vitro cytotoxic effect of HsA was measured in several CRC cells, including SW480, HT29, RKO, DLD-1, and murine CT26. HsA showed significant cytotoxicity in the CRC ...
Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate. T M Larsen et al. Biochemistry, 33(20), 6301-6309 (1994-05-24) The molecular structure of rabbit muscle pyruvate kinase, crystallized as a complex with Mn2+, K+, and pyruvate, has been solved to 2.9-A...
Targeting enzyme sites 19 The structure of pyruvate kinase in the crystalline state has been determined by Muirhead et al. (ref. 4). The active site is thought to lie in a pocket between Domain A and Domain B, with Tyrosine-147 being located at the entrance to the active site. Specific...