This enzyme should not be mistaken for the unrelated enzyme pyruvate dehydrogenase, an oxidoreductase (EC 1.2.4.1), that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA. immunogen KLH-conjugated peptide derived from available PDC sequences including Arabidopsis thaliana antibody format ...
Pyruvate decarboxylase depends on cofactors thiamine pyrophosphate (TPP) and magnesium. This enzyme should not be mistaken for the unrelated enzyme pyruvate dehydrogenase, an oxidoreductase (EC 1.2.4.1), that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA....
Its transport into the mitochondrial matrix is necessary prior to its decarboxylation into acetyl-CoA, which feeds the reducing equivalent-generating tricarboxylic acid (TCA) cycle. Although the existence of specific carrier transport of cytosolic pyruvate into the mitochondria has been inferred from a ...
PyruvateWarburg EffectPyruvate is a key intermediate at the branchpoint of anaerobic and aerobic energy metabolism. Its transport into the mitochondrial matrix is necessary prior to its decarboxylation into acetyl-CoA, which feeds the reducing equivalent-generating tricarboxylic acid (TCA) cycle. Although...
Pyruvate decarboxylase(subunit E1) together withdihydrolipoyl transacetylase(subunit E2) anddihydrolipoyl dehydrogenase(subunit E3) form thepyruvate dehydrogenase complex(PDC; EC 1.2.4.1).PDCcatalyses the conversion of pyruvate to acetyl-CoA and CO2(coupled to the reduction of NAD+to NADH). It links...
The pyruvate dehydrogenase complex (PDC) catalyzes the irreversible decarboxylation of pyruvate into acetyl-CoA. PDC deficiency can be caused by alterations in any of the genes encoding its several subunits. The resulting phenotype, though very heterogeneous, mainly affects the central nervous system. ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook pyruvate Thesaurus Medical Encyclopedia Wikipedia Related to pyruvate:Pyruvate dehydrogenase complex,Pyruvate kinase py·ru·vate (pī-ro͞o′vāt, pĭ-)
Thepyruvate dehydrogenase complex(PDC), a large nuclear-encoded mitochondrial multienzyme complex, is a key regulator of cellular energy metabolism, catalyzing the decarboxylation of pyruvate to acetyl-CoA. PDC is an assembly of three enzymes: pyruvate dehydrogenase (E1), dihydrolipoamideacyltransferase (...
The pyruvate dehydrogenase complex (PDHc) is an intramitochondrial multienzyme system, which plays a key role in aerobic glucose metabolism by catalysing the oxidative decarboxylation of pyruvate to acetyl-CoA. Genetic defects in the PDHc lead to lactic acidemia and neurological abnormalities. In the ...
Pyruvate dehydrogenase is a key enzyme which transforms pyruvate into acetyl-coenzyme A (acetyl-CoA) by pyruvate decarboxylation. Acetyl coenzyme A is the primary raw material for aerobic oxidation of glucose into the Krebs cycle. The activity of pyruvate dehydrogenase can be negatively regulated by ...