CHEMICAL synthesisAROMATIC aldehydesVITAMIN CCancer is a fatal disease with a high mortality rate, followed by infectious and cardiovascular disorders. Consequently, the pursuit of effective and safe anticancer drugs is crucial, constituting a primary objective for medicinal chemists. A...
but it is also particularly challenging. In this work, the synthesis of pyrimidines from lignin β-O-4 model compounds, the most abundant segment in lignin, mediated by NaOH through a one-pot multi
Riki TailorChemistry InternationalSOLANKEE A., TAILOR R. An efficient synthesis of some new chalcone, acetyl pyrazoline and amino pyrimidine bearing 1, 3, 5-triazine nucleus as potential antimicrobial and antitubercular agent. Chem. Int. 2, 189, 2016....
A novel 2-thiopyrimidine/chalcone hybrid was designed, synthesised, and evaluated for their cytotoxic activities against three different cell lines, K-562, MCF-7, and HT-29. The most active cytotoxic derivatives were 9d, 9f, 9n, and 9p (IC50=0.77–1.74 M, against K-562 cell line), 9a...
The development of bis-chalcone (5a-j and 7a-j) involves in the treatment of cyclic imides and vanillin in neutral alumina in microwave solvent free method. Correspondingly the synthesis of pyrazole (6a-j and 8a-j) derivatives has been obtained by the treatment of substituted chalcones and ...
Design, synthesis and biological evaluation of imidazopyridine/imidazopyrimidine-benzimidazole conjugates as potential anticancer agents Design, synthesis and biological evaluation of imidazopyridine/pyrimidine-chalcone derivatives as potential anticancer agents. MedChemComm. 2010; 1(5):355-60.Kamal A, Reddy...
Design, synthesis and biological evaluation of imidazopyridine / pyrimidine - chalcone derivatives as potential anticancer agents A new series of imidazo[2,1-b]pyridine/pyrimidine chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivat... AhmedKamal,J Sure...
General Procedure for the Synthesis of Highly Substituted 6-Amino-N,5,7-Triaryl-2- (Phenylamino)Pyrazolo[1,5-a]Pyrimidine-3-Carboxamide (3a-z) A solution of α-azidochalcone 1 (1 mmol), 3-amino-N-aryl-5-(phenylamino)-1H-pyrazole-4-carboxamide 2a–c (1.5 mmol), and sodium ...
Ultrasound-assisted synthesis of dihydropyrimidine-2-thiones Chalcone derivatives were prepared by the condensation of various substituted aryl aldehydes and acetophenone in alkaline ethanol, while pyrimidine-2-thion... J Safaei-Ghomi,A Ghasemzadeh - 《Journal of the Serbian Chemical Society》 被引...
Design, synthesis, and evaluation of 2-aryl-7-(3',4'-dialkoxyphenyl)-pyrazolo(1,5-a)pyrimidines as novel PDE-4 inhibitors. Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3',4'-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibito...