This chapter discusses the biosynthesis of purines and pyrimidines. The vitamin, folic acid, is converted to its coenzyme form, tetrahydrofolic acid, by a pyridine nucleotide-dependent enzyme, dihydrofolate reductase. In turn, tetrahydrofolate serves as the carrier of various one-carbon groups that ...
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides ArticleOpen access19 May 2017 Background Purines are key components of all living cells on earth, required for energy metabolism and biosynthesis of RNA and DNA. Purine biosynthesis pathways were first described in the 1950'...
Synthesis of pyrimidine nucleotides in cancer cells utilizes glucose and glutamine for the carbon of the uracil and cytosine rings, which then condense with the ribose subunit primarily derived from glucose via the pentose-phosphate pathway (1, 3). The purine nucleotides are synthesized by building ...
These C1 units are used in a wide variety of biosynthetic pathways including the synthesis of methionine, inosine monophosphate, other purines and some pyrimidines (e.g. thymidine and hydroxymethyl cytidine). The serine biosynthetic pathway shown in Fig. 1 is generally available to a wide variety...
the addition of methionine was not effective in reducing the toxicity of the fungicide againstF.graminearum. These results indicate that cystathionine γ-synthase may not be a primary target of anilinopyrimidine fungicides, at least, inF.graminearum(Fu et al.2013). On the other hand, there are ...
(adenine and guanine) and three pyrimidines (thymine, cytosine and uracil) [2]. Cancer is however defined as a group of more than 100 different diseases that is caused by multiple changes in cellular DNA and RNA, and it is characterized by uncontrollable growth (mitosis) in which cells are...
Annals of Nutrition & MetabolismGrobner W, Zollner N: The influence of dietary purines and pyrimidines on purine and pyrimidine biosynthesis in man Nutr Metab 1977; 21 (1-3): 26-32W. Grobner, N. Zollner, The influence of dietary purines and pyrimidines on purine and pyrimidine...
(adenine and guanine) and three pyrimidines (thymine, cytosine and uracil) [2]. Cancer is however defined as a group of more than 100 different diseases that is caused by multiple changes in cellular DNA and RNA, and it is characterized by uncontrollable growth (mitosis) in which cells are...
Synthesis of both purines and pyrimidines requires the synthesis of the nitrogenous base and ribose, derived from the pentose phosphate pathway (Figure 1). mTORC1 transcriptionally activates the pentose phosphate pathway (Düvel, et al., 2010), so mTORC1 can indirectly contribute to the ...
metabolites in resistant versus parental cells revealed a strong accumulation of all the intermediates of the pyrimidine biosynthetic pathway (pyr-P) (Figure 4C) and a significant increase of the main purine biosynthetic pathway (pur-P) intermediates, namely FGAR, FAICAR, AICAR, and SAICAR (...