Ushimaru for critical reading of the manuscript; F. Kudo, T. Eguchi and T. Ueda for instruction on the stopped flow apparatus; and H. Zhang, F. Hayashi and Y. Ishii for measurement of NMR spectra at RIKEN Yokohama. Author information Author notes These authors contributed equally: Lena ...
when the biosynthesis of pyrimidines is to be regulated CTP binds to ATCase to stop the synthesis. This is known as feedback inhibition, where the last product of the pathway inhibits the first enzyme to regulate the synthesis. This is achieved when high levels of CTP are present in the ce...
Pascale et al. (2011) performed a high-throughput screening of three small molecule libraries (2,200 compounds) and identified six inhibitors of homoserine kinase (Thr1p) fromS. cerevisiae,S. pombe, andC.neoformans. Two out of six compounds (Fig.2h, i) exhibited antifungal activity and their...
Review ReportsVersions Notes Abstract Purine nucleotides are indispensable compounds for many organisms and participate in basic vital activities such as heredity, development, and growth. Blocking of purine nucleotide biosynthesis may inhibit proliferation and development and is commonly used in cancer therap...
9. Notes Added in Proof 9. Notes Added in Proof While this article was under review, the first crystal structure of a eukaryotic mARC was rWesohlivledth, tishearhtuicmleawn amsAuRnCde1r[1re2v3]ie. w, the first crystal structure of a eukaryotic mARC was resolved, the human mARC1 [...
Review ReportsVersions Notes Abstract When subjected to a certain degree of mechanical damages, a systematic responsive mechanism of fresh-cut cucumber is activated. Among them, the lignin produced in the secondary metabolism will make the fresh-cut cucumber lignified, which will increase the hardness...
Finally, the recruitment of glycine in the RNA World chemistry was justified by its involvement in the synthesis of purines. The biogenesis of the glycine is among the simplest ones, and involves a tetrahydrofolate precursor (also involved in construction of purines), carbon dioxide, and ammonia...
The toxins are chemically diverse, and include macrolides, cyclic polyethers, spirolides and purine alkaloids. Whereas there is a multitude of studies describing the pharmacology of these toxins, there is limited or no knowledge regarding the biochemistry and molecular genetics involved in their ...