The sequence for Ib is the same except that py coordinated at the v site of Ib is protonated in preference to py at sites x . The μ 4 -oxo group of Ia and Ib and the OH groups of diprotonated IIIa are less basi
Phenylacetic acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides ...
acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides diphenylurea[31]....
Phenylacetic acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides ...
If the basic substance is not used in the reaction with chloroformic acid ethyl ester, then hydrochloride is obtained, where the free base is obtained by treating it with basic substances (tertiary amines, for example, triethylamine). For example, in a solution of 21.3 kg of 2,6-dichloro-...
If the active compound(s) is substantially insoluble, it ordinarily is milled to a particle size of less than 200 mesh. If the active compound(s) is substantially water soluble, the particle size is normally adjusted by milling to provide a substantially uniform distribution in the formulation,...
or in the presence of an appropriate base such as pyridine, in a suitable solvent, such as dimethylformamide; or alternatively, an amine can be converted into an amide by reaction with an acyl chloride in pyridine or in the presence of a base such as triethylamine in a suitable solvent such...
Examples of the base include organic bases such as triethylamine, diisopropylethylamine, potassium hexamethyldisilazide, 1,8-diazabicyclo[5.4.0]-undec-7-ene, n-butyllithium and potassium tert-butoxide; and inorganic bases such as sodium carbonate, potassium carbonate, cesium carbonate and sodium ...
Accordingly, there is the need to provide compounds characterized by a 6-membered heteroaryl substituent on an imidazo[1,2-a]pyridine in position 5 of the central pyridine ring which show lower inhibition of the P450 isoenzymes, represented by IC50 values greater than 5 μM....
butyloxalylchloride to form the dioxamate. The reaction is carried out in base and solvent at the standard conditions, as exemplified by the art. Examples of suitable solvents are dimethylformamide, dioxane, and tetrahydrofuran. Appropriate bases include triethylamine, N-methylmorpholine, dimethylpiperazine...