Phenylacetic acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides ...
Similar alkylation with bromoacetophenone is followed by in situ condensation to give 3-aminothieno[2,3-b]pyridines in good yield (Equation 85). Alkylation of 2-pyridinethiones with α-bromoacetates has also been achieved using triethylamine as base in acetonitrile <2001T8845>. (85) 2-...
acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides diphenylurea[31]....
The sequence for Ib is the same except that py coordinated at the v site of Ib is protonated in preference to py at sites x . The μ 4 -oxo group of Ia and Ib and the OH groups of diprotonated IIIa are less basic than their respective ligands py and N. Implications of the ...
Habib and Rees prepared 5a via the acid chloride, reacting picolinic acid 3 and thionyl chloride in benzene, then adding N- methylaniline dropwise and heating at reflux; Okamoto activated acid 3 as the mixed anhydride by reaction with ethyl chloroformate and triethylamine, before adding N-...
Phenylacetic acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides ...
Unless otherwise specified, the terms “enriched in one isomer”, “enriched in isomers”, “enriched in one enantiomer” or “enriched in enantiomers” refer to the content of one of the isomers or enantiomers is less than 100%, and the content of the isomer or enantiomer is greater than ...
The net result is that less than 5% of the infected population are treated. Likewise of the 530 million individuals worldwide who carry the HSV-1 virus, 81% of the symptomatic population remain untreated. No cure exists for HSV infection, and once infected, individuals carry the virus for ...
basic lead silicate or lead chromate. The pigments may be dispersed using a grind resin or a pigment dispersant. The pigment-to-resin weight ratio in the electrocoat bath can be important and should be preferably less than 50:100, more preferably less than 40:100, and usually about 10 to...
(CH2)pOR3, Ar2 denotes phenyl, which is unsubstituted or mono-, di- or trisubstituted by A, Hal, (CH2)nOH, (CH2)nOA, (CH2)nNH2, (CH2)nNHA, (CH2)nNA2, SO2NH2, SO2NHA, SO2NA2, (CH2)nCONH2, (CH2)nCONHA, (CH2)nCONA2, [C(R3)2]nN(R3)2, CONH(CH2)pCH[(CH2)nN(R3)2...