2-Methyl-1H-pyrrolo[2,3-c]pyridine is insoluble in most common organic solvents but is soluble in water and alcohols 〈77CHE1224〉. Derivatives of pyrrolopyridines containing hydroxy, amino, or carbonyl groups tend to be soluble in polar solvents such as water and alcohols and much less ...
Phenylacetic acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides ...
Habib and Rees prepared 5a via the acid chloride, reacting picolinic acid 3 and thionyl chloride in benzene, then adding N- methylaniline dropwise and heating at reflux; Okamoto activated acid 3 as the mixed anhydride by reaction with ethyl chloroformate and triethylamine, before adding N-...
The sequence for Ib is the same except that py coordinated at the v site of Ib is protonated in preference to py at sites x . The μ 4 -oxo group of Ia and Ib and the OH groups of diprotonated IIIa are less basic than their respective ligands py and N. Implications of the ...
acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides diphenylurea[31]....
If the active compound(s) is substantially insoluble, it ordinarily is milled to a particle size of less than 200 mesh. If the active compound(s) is substantially water soluble, the particle size is normally adjusted by milling to provide a substantially uniform distribution in the formulation,...
acid is found to react with phenyl isocyanate in 1,2-dichloroethane at 24°C to give the amide in 66 % yield in less than 5 min; whereas on using the same amount of pyridine only 53% could be isolated after 2h. With triethylamine, only very little is formed besides diphenylurea[31]....
Determination of the proper dosage for a particular situation is within the skill of the art. Generally, treatment is initiated with smaller dosages which are less than the optimum dose of the compound. Thereafter, the dosage is increased by small increments until the optimum effect under the ...
Generally, treatment is initiated with small dosages substantially less than the optimal dose of the compound. Thereafter, the dosage is increased by small increments until efficacy is obtained. In general, the compounds of this invention are most desirably administered at a concentration level that...
A particularly suitable base is triethylamine. If desired, the reaction can be conducted in the presence of a solvent such as, for example, water, ketones, chlorinated hydrocarbons, mixtures thereof and the like. Particularly suitable solvents include, for example, methylene chloride and acetone. ...