These effects are thought to be due to secondary consequences of the interference with protein synthesis, rather than to a direct effect of puromycin on the synthesis of nucleic acids. Density gradient centrifugation of nucleic acids extracted from HeLa cells has shown that the molecular species of...
Puromycin was found to inhibit the synthesis of peptide-bound hydroxyproline more than it inhibited the incorporation of proline into protein, indicating ... JJ Jeffrey,GR Martin - BBA - General Subjects 被引量: 110发表: 1966年 Protein synthesis in erythroid cells : II. Polyribosome function ...
Preincubation of late-cleavage stages in thymidine greatly reduces the extent of inhibition of its incorporation by puromycin and cycloheximide, suggesting that thymidine may have been converted to other DNA precursors, and that the incorporation of these into DNA is less sensitive to protein synthesis...
1964. Puromycin inhibition of pro- tein synthesis. Incorporation of puromycin into peptide chains. Proc. Natl. Acad. Sci. 51:585- 592... MA Darken - 《Pharmacological Reviews》 被引量: 107发表: 1964年 Protein synthesis in erythroid cells : II. Polyribosome function in intact reticulocytes In...
1. The effect of puromycin aminonucleoside (PA) on the incorporation of adenine, formate, and inorganic phosphate into rat-kidney RNA was studied. PA, administered in multiple doses of 15 mg/kg for 5 days, neither inhibited purine biosynthesis de novo, nor activated the salvage pathway, as ...
Yarmolinsky MB, De La Hara,G.L. Inhibition by puromycin of amino acid incorpora‐ tion into protein. Proc Natl Acad Sci USA 1959;45:1721-1729.Inhibition by puromycin of amino acid incorporation into protein - Yarmolinsky, Haba, et al. - 1959...
Neupert, W, Sebald, W, Schwab, AJ, Pfaller, A, Bucher, T (1969) Puromycin sensitivity of ribosomal label after incorporation of 14C-labeled amino acids into isolated mitochondria from Neurospora crassa. Eur. J. Biochem 10: pp. 585-588...
Puromycin led either to stimulation or to inhibition of phenylalanine incorporation in cell-free systems from Bacillus licheniformis and Bacillus stearothermophilus 10. Stimulation was observed at low puromycin concentrations, at high puromycin concentrations in the presence of excess transfer RNA, and over...
Biosynthetic incorporation of L-leucine into the indole alkaloids. The effect of puromycindoi:10.1016/S0040-4039(01)84900-5DonaldC.WigfieldandBettyLemandV.SrinivasanSDOSTetrahedron LettersRinehart K L J, Malik J M, Nystrom R F, et al. Biosynthetic incorporation of [1-13C] glucosamine(*) and...