Johnson MD, Bao HF, Helms MN, Chen XJ, Tigue Z, Jain L, Dobbs LG, Eaton DC. Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport . Proc Natl Acad Sci USA 2006; 103 :4964–4969...
Aortic artery smooth cells ADAM17: A disintegrin and metalloproteinase 17 AECs: Alveolar epithelial cells AKT: Protein kinase B AT1: Alveolar type I AT2: Alveolar type II BMPR2: Bone morphogenic protein receptor 2 C/EBPβ: CCAAT/enhancer-binding protein beta ...
Dobbs LG, Gonzalez R, Williams MC 1986 An improved method for isolating type 2 cells in high yield and purity. Am Rev Respir Dis 134:141-145 12. Walther FJ, Wade AB, Warburton D, Forman HJ 1991 Augmentation of superoxide dismutase and catalase activity in alveolar type I1 cells. Am J...
The inclusions were located mainly in the cytoplasm of type I alveolar lining cells, appeared 40 minutes after the injection, and lasted up to 2 days. These observations suggest that the type I alveolar lining cells participate in the clearing mechanism of the lung tissue, a function that thus...
Wide alveolar-arterial (A-a) gradient for oxygen (calculator: A-a O2 gradient)CBC: Leukocytosis may be present.Troponins:[5,29] May be elevated in 50% of patients with moderate-to-large emboli. Associated with an increased risk of mortality Normal results on highly sensitive assays have...
lungs where they constitutively reside in the microvasculature with a broad distribution in peribronchiolar and interalveolar capillaries.13 Information from human studies is less compelling, although NKT cells have been detected in BAL14 and sputum15 at very low frequencies (0.1–0.2% of T cells)....
This chapter discusses the maintenance of human and rat pulmonary type II cells in an organotypic culture system. The lungs of mammals and some inframammalian vertebrates contain a potent surface-active material that coats the alveolar surface, decreases the surface tension, and thus stabilizes the ...
Pulmonary alveolar proteinosis. In alveoli of patients with PAP, anti-GM-CSF antibodies produced by B-cells block binding of the GM-CSF to alveolar macrophages (AM), which leads to impaired lipid metabolism and undegraded surfactants. Show moreRead full chapterView PDFExplore book Primary ...
Struhar DJ, Harbeck RJ, Gegen N, Kawada H, Mason RJ. Increased expression of Class Il antigens of the major histocompatibility complex on alveolar macrophages and alveolar type II cells and interleukin (IL-1) secretion from alveolar macrophages in an animal model of silicosis. Clin. Exp. Immun...
Derived AOs contained the expected spectrum of differentiated cells, including alveolar progenitors, type 1 and 2 alveolar epithelial cells and mesenchymal cells. Treatment with transforming growth factor (TGF-β1) induced fibrotic changes in AOs, offering a PF model for therapeutic evaluation of a ...