Parathyroid Hormone (PTH) Promotes the Release of H+ by Osteoclasts via the ATF3/V-ATPase Signaling Pathwaydoi:10.1681/ASN.20233411S1488dShuting DengGuangdong Provincial People's Hospital, Guangzhou, China .American Society of NephrologyJournal of the American Society of Nephrology...
The correct answer isb. Parathyroid hormone (PTH). Theparathyroid hormone (PTH)promotes an increase in the activity of osteoclasts. PTH increases... Learn more about this topic: Parathyroid Gland: Calcium Metabolism, Osteoclasts & PTH from
PTH promotes secretion of TRANCE/RANKL and periostin through PTH1R binding on osteoblasts and/or bone marrow stromal cells TRANCE/RANKL induces differentiation of osteoclasts, which in turn promote release of Ca++ from bone. PTH1R on osteocytes, however, allows PTH to promote bone formation and ...
The PTH/PTHrP receptor binds to two ligands with distinct functions: the calcium-regulating hormone, parathyroid hormone (PTH), and the paracrine factor, PTH-related protein (PTHrP). Each ligand, in turn, is likely to activate more than one receptor. The functions of the PTH/PTHrP receptor we...
One of these factors is parathyroid hormone-related protein (PTHrP), which plays an important role in the local bone breakdown that is characteristic of tumor-induced osteolysis [2], [5], [6]. PTHrP was initially identified as the factor responsible for humoral hypercalcemia of malignancy (...
Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1 Secreted frizzled-related protein (sFRP)-1 is a Wnt antagonist that when deleted in mice leads to increased trabecular bone formation in adult animals afte... PVN Bodine,...
(8-10). TRANCE/RANKL induces differentiation of osteoclasts, which in turn promote release of Ca++from bone (1, 8, 9). PTH1R on osteocytes, however, allows PTH to promote bone formation and IGF-1 production (11, 12). In renal epithelium, PTH promotes conversion of Vitamin D to its ...
The bone catabolic actions of parathyroid hormone (PTH) are seen in patients with hyperparathyroidism, or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH’s anabolic effects on bone. To determine it...
J. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Cell. Mol. Life Sci. 68, 1–13 (2011). CAS PubMed Google Scholar Kousteni, S. & Bilezikian, J. P. The cell biology of parathyroid hormone in osteoblasts. Curr. Osteoporos. Rep. 6...
the MY-3 mimetic peptide promotes osteoblast differentiation and has a very good effect in treating osteoporosis and promoting bone growth. The anti-osteoporosis effect of the MY-3 mimetic peptide is better than that of the PTH (1-34) (The product name on the market is Forsteo or Parathyroid...