Boyer JL, et al. Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol. Clin Pharmacol Ther 2020...
[4] Núñez F P, Quera P R, Gomollón F. Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation. Colangitis esclerosante primaria y enfermedad inflamatoria intestinal: interrelación intestino-hígado. Gastroenterol...
Boyer JL, et al. Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol. Clin Pharmacol Ther 2020;108(6):1213–1223. ...
We conclude that Klf5 is required for the normal function of the hepatobiliary system and that the K5-Cre ; Klf5 fl/fl mouse is an excellent model to probe the molecular events interlinking damage and regenerative response in the liver.
自身免疫性肝脏疾病(autoimmune liver disease,AILD)主要包括以肝脏实质细胞炎症损伤为主的自身免疫性肝炎(autoimmune hepatitis,AIH)、以慢性肝内胆汁淤积为特征的原发性胆汁性胆管炎(primary biliary cholangitis,PBC)和以特发性肝内外胆管炎症和纤维化为特征的原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)[1...
Lay summary: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease characterized by progressive bile duct destruction. One serious complication of PSC is reduced bone mass resulting in increased fracture risk. Herein, we demonstrate that Th17 cells mediate bone loss in PSC by inducing ...
30、c Acid Withdrawal in Patients With Primary Sclerosing CholangitisJ. Hepatology,2014,60(3):931-940.原发性硬化性胆管炎(PSC)PSC定义PSC诊治推荐意见 治疗 内镜治疗 由于胆汁排出受阻和病原微生物的过度生长,PSC患者易出现频发胆管狭窄和结石。PSC所致的胆道梗阻累及各级胆管树,从微观胆小管到肝外胆管,内镜治...
Results Objective Primarysclerosingcholangitis(PSC)isachroniccholestaticliverdiseaseoftenleadingtoend-stageliverdisease.Itspathogenesisremainslargelyunknown,althoughfrequentconcomitantIBDhintstowardscommonfactorsunderlyinggutandbileductinflammation.Consideringthemountingevidenceontheinvolvementoftheintestinalmicrobiotaininitiatingand...
In this article, the authors discuss aspects regarding the association between primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). They are critical on the study by L. Marelli and colleagues about the implication of liver transplantation (LT) on inflammatory bowel disease (IBD). An ...
Controls without liver disease are identified with assistance of the Mayo Clinic Biobank. Participant consent is obtained at the beginning of the recruitment process by mail-in, electronic or face-to-face protocols. Clinical data is extracted from the medical record by qualified physicians and ...