除非怀疑存在小胆管PSC或与自身免疫性肝炎(autoimmune hepatitis)重叠的PSC,否则肝脏活检不是诊断所必需的。肝核磁共振弹性造影和瞬态弹性造影(magnetic resonance elastography and transient elastography)是评估组织的机械特性,如纤维化,等的非常...
自身免疫性肝脏疾病(autoimmune liver disease,AILD)主要包括以肝脏实质细胞炎症损伤为主的自身免疫性肝炎(autoimmune hepatitis,AIH)、以慢性肝内胆汁淤积为特征的原发性胆汁性胆管炎(primary biliary cholangitis,PBC)和以特发性肝内外胆管炎症和纤维化为特征的原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)[1...
检索采用英文主题词为"primary sclerosing cholangitis,autoimmune pancreatitis,IgG4,autoimmune overlap syndrome,cholangiocarcinoma"等。流行病学、诊断、治疗等方面的关键词为"prevalence,incidence,ursodeoxycholic acid,serum marker,ERCP,MRCP,immunosuppres...
In conclusion, PSC-AIH variant is not so uncommon and distinction of this clinical entity is of major importance, as outcomes may differ from those in patients with a diagnosis of classic autoimmune liver disease. However, overdiagnosis should be avoided in order not to expose unnecessarily PSC ...
Factors Associated With Response to Therapy and Outcome of Patients With Primary Biliary Cirrhosis With Features of Autoimmune HepatitisJ. Clin Gastroenterol Hepatol, 2014,12(5):863-869.PB 8、C定义PBC诊治推荐意见原发性胆汁性肝硬化(PBC) 肝移植 肝移植是治疗终末期 PBC唯一有效的方式。PBC患者肝移植...
- Exposure to toxins like heavy metals or pesticides could contribute to disease risk. ### 4. **Hygiene Hypothesis** - Living in an overly clean environment (low microbial exposure) may lead to an underdeveloped immune system, increasing the risk of autoimmune diseases. ...
Autoimmune hepatitis (AIH) is less common in patients with IBD than PSC, however, an association has been observed. A small subgroup may have an overlap syndrome between AIH and PSC and management should be individualised dependant on liver histology, serum immunoglobulin levels, autoantibodies, ...
We are looking to raise as much money as possible for PSC support who are the only UK charity dedicated to improving the lives of people affected by the rare, autoimmune liver disease, Primary Sclerosing Cholangitis (PSC). PSC has no cure or medical treatment and donating to my fundraising ...
PSC可与其他自身免疫介导的肝脏疾病并存,主要为与自身免疫性肝病(autoimmune liver disease,AIH)重叠,大约6%～9%的PSC患者合并AIH[4]。PSC与炎症性肠病(inflammatory bowel disease,IBD)存在密切关系,尤其以溃疡性结肠炎(ulcerative colitis,UC)多见。儿童PSC并发症中UC的发病率最高,约占6.4%～7.8%[5]。UC是一...
近年来,自身免疫性肝病(Autoimmune Liver Disease,ALD)受到越来越多医学研究者的关注。自我免疫性肝病是一类由异常自身免疫反应引起的肝胆炎症性疾病,主要包括自身免疫性肝炎(Autoimmune Hepatitis,AIH)、原发性胆汁性胆管炎(Primary Biliary Cholangitis,PBC)与原发性硬化性胆管炎(Primary Sclerosing Cholangitis,PSC)。2024...