mTOR exists as two multimeric functional complexes termed mTOR complex 1 (mTORC1) and mTORC2. Herein, we first cloned ribosomal protein S6 (rpS6, a downstream molecule of mTORC1) and protein kinase C (PKC, a downstream effector of mTORC2) from the testis of Eriocheir sinensis. The dynamic...
mTORC1/rpS6 signaling complex promoted Sertoli blood-testis barrier (BTB) remodeling by perturbing Sertoli cell-cell adhesion site known as the basal ectoplasmic specialization (ES). mTORC1/rpS6 complex als...
先弄清楚概念：PS6K1是核糖体蛋白S6激酶，PS6是磷酸化核糖体蛋白S6，是两个不同的主体。再看功能：第一个是第二个蛋白的激酶，也就是说核糖体蛋白S6需要活化的p-S6K1来激活（通过磷酸化核糖体S6变成 将S6变成p-S6），S6需要P-S6K1来激活变成p-S6。S6K1本身又是被mTORC1激活的。
p-rps6控制分裂细胞中mrna结合水平的翻译,p-rps6(s235/236)也由ras/raf/erk/rsk信号诱导,p-rps6被募集到7-甲基鸟苷帽结构。 5、pi3k/akt/mtorc1/s6k通路是上调哺乳动物细胞中rps6磷酸化的主要信号通路。rps6是首个被鉴定的s6k1(p70s6kα)底物,rps6的磷酸化已被广泛认为是pi3k/akt/mtorc1下游激活的标志...
FLT3-ITD activates RSK1 to enhance proliferation and survival of AML cells by activating mTORC1 and eIF4B cooperatively with PIM or PI3K and by inhibiting bad and BIM. Cancers (Basel). 2019;11(12):1827. https://doi.org/10.3390/cancers11121827. Article CAS PubMed Google Scholar Jin G, ...
Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-...
which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 ...
22 Recent studies have shown that the LINC00961-encoded SPAR polypeptide, conserved between human and mouse, interacts with the lysosomal v-ATPase to negatively regulate mTORC1 activation and regulate muscle regeneration.30 There are also reports that the ribosome profile can identify hundreds of ...
Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the ...
mTORC1/rpS6 complex also promoted disruption of spermatid adhesion at the Sertoli-spermatid interface called apical ES. Herein, we performed analyses using the adjudin (a potential non-hormonal male contraceptive drug) model, wherein adjudin was known to perturb apical and basal ES function at ...