However, the role of Prp19 in tumor biology is still elusive. Here, we reported that Prp19 arrested cell cycle in HCC cells via regulating G2/M transition. Mechanistic insights revealed that silencing Prp19 inhibited the expression of cell division cycle 5-like (Cdc5L) via repressing the ...
Urano‐Tashiro Y, Sasaki H, Sugawara‐Kawasaki M, Yamada T, Sugiyama A, Akiyama H, Kawasaki Y, Tashiro F. Implication of Akt‐dependent Prp19 alpha/14‐3‐3beta/Cdc5L complex formation in neuronal differentiation. J...
目的探讨十九号复合物组成因子PRP19,SPF27,CDC5L和PLRG1的mRNA在肝细胞癌中的表达情况及其与患者生存率的关系.方法在NCBI的GEO数据库和TCGA数据库中分别检索肝细胞癌表达谱的数据集,采用Stata进行统计分析,Kaplan-Meier法绘制TCGA数据库中肝细胞癌患者的生存曲线.结果共纳入1033例肿瘤组织和679例正常组织,合并效应...
Num1 interacts with components of the Prp19/Cdc5L complex.Nikola, KellnerKai, HeimelTheresa, ObhofFlorian, FinkernagelJörg, Kämper