PRP-19是剪接体组装过程中NTC（NineTeen Complex）的核心组分之一【9】。该研究团队进一步验证了NTC其他核心组分以及剪接体的其他组成蛋白是否也能参与调控线粒体应激条件下UPRmt的激活，结果显示NTC其他组分基因的敲低均能显著抑制线粒体应激条件下UPRmt的激活，编码剪接体其他组分蛋白的基因中约有50%的基因也都能参与...
C. et al. The Prp19 complex directly functions in mitotic spindle assembly. PLoS One. 8, e74851 (2013).Hofmann, J. C., Tegha-Dunghu, J., Dra¨ger, S., Will, C. L., Lu¨hrmann, R., and Gruss, O. J. (2013) The Prp19 complex directly functions in mitotic spindle assembly....
It assesses whether Syf1, a component of the Prp19 complex, interacts biochemically with the TREX complex. Findings reveal that the Prp19 complex has a second function in gene expression in yeast, namely in transcription elongation.Chanarat
Here, we report that the spliceosomal Prp19 complex modifies Prp3, a component of the U4 snRNP, with nonproteolytic K63-linked ubiquitin chains. The K... EJ Song,SL Werner,J Neubauer,... - 《Genes & Development》 被引量: 278发表: 2010年 Systematic Two-Hybrid and Comparative Proteomic ...
因此我們推測PRP19 與至少一個剪接分子形成一個蛋白複合體(protein complex),我們已在一酵母菌株中將其PRP19基因的3'端接上一段序列,使其產生的PRP19 蛋白質之C端帶有一個會被單株抗體12CA5認識的抗原決定基.我們另將此單株抗體接到管柱內用以分離PRP19蛋白複合體.我們發現在此複合體內大約包含7個蛋白質 (...
protein polyubiquitinationspliceosomal tri-snRNP complex assemblyspliceosomal complex assemblymRNA splicing, via spliceosomeinner cell mass cell proliferationtranscription-coupled nucleotide-excision repairdouble-strand break repair via nonhomologous end joininglipid biosynthetic processproteasomal protein catabolic process...
protein polyubiquitination spliceosomal tri-snRNP complex assembly spliceosomal complex assembly mRNA splicing, via spliceosome inner cell mass cell proliferation transcription-coupled nucleotide-excision repair double-strand break repair via nonhomologous end joining lipid biosynthetic process proteasomal protein cat...
Changes within the spliceosome upon binding of the PRP19-associated complex include remodeling of the U6/5' splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence. 包装清单: 产品编号 产品名称 包装 AF2026 PRP19 Rabbit Monoclonal ...
complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and ...
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome Genes Dev., 24 (2010), pp. 1434-1447 Google Scholar Spector and Lamond, 2011 D.L. Spector, A.I. Lamond Nuclear speckles Cold Spring Harb. Perspect. Biol., 3 (2011), p. 3 Go...