Kooy H and Lu H-M 2006 Optimization of current modulation function for proton spread-out Bragg peak fields Med. Phys. 33 1281Lu HM, Kooy H. Optimization of current modulation function for proton spread-out Bragg peak fields. Med Phys. 2006;33(5):1281-87....
Despite a modest LET (~19 keV/μm), antiproton spread out Bragg peak (SOBP) irradiation caused significant residual γ-H2AX foci compared to X-ray, proton and antiproton plateau irradiation. RBE of ~1.48 in the SOBP and ~1 in the plateau were measured and used for a qualitative ...
This work presents an attempt to addressing the issue of RBE variation in a spread-out Bragg peak (SOBP) of protons based on nanodosimetric track structure analysis. Ionization track structure has been simulated using Geant4-DNA for protons of 100 MeV initial energy propagating in water. The...
Fig. 1.Depth dose curves (relative percentage dose vs depth in tissue) for an unmodulated proton beam (Bragg peak), a modulated proton peak (spread out Bragg peak or SOBP), and 10-MV photons. The SOBP has been modulated to treat a tumor that extends from approximately 9 to 16cm in ...
In proton beam therapy, a Spread-Out Bragg peak (SOBP) is used to establish a uniform dose distribution in the target volume. In order to create a SOBP, several Bragg peaks of different ranges, corresponding to different entrance energies, with certain intensities (weights) should be combined ...
Purpose: The magnitude and the trend of variation of the output factor (OF) for range‐modulated spread‐out Bragg peak (SOBP) proton beams are investigated as a function of the range, modulated SOBP width and field size.Method and Materials: The proton delivery system of the fix horizontal ...
A 68 MeV proton beam was turned into a spread out Bragg peak with a water equivalent range of 23.7 mm and a modulation of 22.0 mm for irradiation. The tip of the tube containing the samples were positioned in the center of the irradiation field in 11.0 mm water equivalent depth. For ...
The proton planning system and facility are advanced, which makes PBT increasingly precise over time. The target volume is usually larger than the high-dose covered by the Bragg peak. Spread-out Bragg peaks (SOBP) are needed to make sure every tissue element in the target receives the same ...
One-day-old ZFE were irradiated over a wide dose range (15–95 Gy) in three different beams (proton entrance channel, proton spread out Bragg peak and 30 MeV electrons) at UHDR and reference dose rate. After irradiation the ZFE were incubated for 4 days and then analyzed for four differe...
The block combination and proton beams were chosen so that the measured dose by the PPC was about 50% of the dose at the center of spread out Bragg peak (SOBP) for each beam. A parallel plane chamber (PPC) was used to measure the dose at the center of SOBP and immediately behind ...