That indicates that on a global scale this organism is believed to be the most common bacterial cause of acute respiratory infections, and is estimated to result in one million childhood deaths each year, mostly in developing countries (Stansfield, S. K., Pediatr. Infect. Dis., 6: 622 (...
phages and mobile genetic elements. Acrs typically inactivate CRISPR systems by directly interacting with Cas proteins to prevent DNA cleavage or target DNA binding7. In addition, some Acrs possess enzymatic activities to modify Cas proteins post-translationally25,26. There are on-going efforts to id...
We showed that expression of either human ortholog, COQ10A or COQ10B, rescues yeast coq10Δ mutant phenotypes, restoring the function of respiratory-dependent growth on a nonfermentable carbon source and sensitivity to oxidative stress induced by treatment with PUFAs. These effects indicate a ...
The invention relates toVibrio cholefrae, Rbm (rugosity and biofilm structure modulator) proteins and the rbm polynucleotides and genes that encode them. BACKGROUND Vibrio cholerae, the etiologic agent ofcholera, is found naturally in environmental aquatic habitats both as a free-living organism and...
soluble proteins are degraded by the proteasome To study the mechanism of USPD, we sought proteins that function in small complexes consisting of two or three subunits with well-defined interaction interface because structural information could potentially reveal the cause of their instability on ...
aeruginosa.26, 27, 28 These proteins are all homodimers, with each monomer consisting of two highly conserved domains: a predominantly helical dimerization domain and a helix–turn–helix plus a characteristic winged-helix (WH) DNA binding domain. Although the helix–turn–helix and WH motifs ...
ber that all three domains rely on DNA to store and rep- and the architecture of the bacterial genome requires Compared with mRNA, rRNA licate genetic information. In each domain the genetic an understanding of the basic organization of the and tRNA are chemically very material has to be ...
Ribonucleotide reductase (RNR) is an important enzyme that mediates the conversion of ribonucleotides to deoxyribonucleotides, the DNA precursors. This reaction is essential for DNA biosynthesis during S-phase of the cell cycle and DNA repair mechanisms (Reichard et al.1961; Hofer et al.2012). ...
The hrpRS genes are transcribed as an operon, pro- posed to form a functional heteromeric HrpRS AAA + complex of unknown quaternary structure8. The advantage that such a dual EBP system confers on T3SS-mediated pathogenicity in Ps is unclear. Multiple sensory systems as well as abiotic...
The former is associated with greater risk as virulence factors are generally located on mobilizable genetic elements that may be acquired from wild-type organisms. Metabolic genes, meanwhile, are generally located on the chromosome, so attenuations at these sites are more stable [23]. The fourth...