The use of the polypeptide in the diagnosis, screening and treatment of carcinoma, e.g. breast cancer, pancreatic cancer, lung cancer, liver cancer, ovarian cancer, colon cancer and/or osteosarcoma, is also provided.テレット ジョナサン アレキサンダー...
IGFBP-1, a secreted phosphoprotein, is generally highly phosphorylated and inhibitory to IGF action; however a hypophosphorylated form of IGFBP-1 can potentiate IGF-1-mediated cell proliferation [17], and IGFBP-1 is known from non-cancer studies to promote migration through integrin signaling [37]...
The IRS proteins function as essential signaling intermediates downstream of many cell surface receptors that have been implicated in cancer. For example, the IRS proteins are major downstream effectors of the Insulin-Like Growth Factor-1 (IGF-1) receptor (IGF-1R) and they play a critical role ...
In line with the central role of Wnt/β-catenin signaling in intestinal stem cell maintenance, hyperactivation of this pathway is the hallmark feature of colorectal cancer (CRC). In the majority of CRC patients, this hyperactivation is caused by either inactivatingAPCmutations or activating mutations...
Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair Cos, Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair, J. Pineal ... Alonso...
To address this problem, we designed a systems-level approach investigating the neighbourhood of mutated or differentially expressed cancer-related proteins in four major solid cancers (colon, breast, liver and lung). Using signalling and protein–protein interaction network resources integrated with ...
Ankle1 is a nuclease likely involved in DNA damage repair pathways and single nucleotide polymorphisms in the Ankle1 gene have been linked to increased breast and ovarian cancer risk. In this review we describe potential mechanisms of the involvement of LEM proteins, particularly of LAP2α and ...
A group of significantly cancer-related RBPs was identified • The effect of NSUN6, ZC3H13, BYSL, ELAC1, RBMS3, and ZGPAT on cell viability was shown Summary RNA-binding proteins (RBPs) regulate the expression of thousands of transcripts, and some are reported to be involved in human ...
The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein — small integrin-binding ligand N-linked glycoproteins (SIBLINGs) — are emerging as important players in many stages of cancer ...
et al. Amplification and expression of the HMGIC gene in a benign endometrial polyp. Genes Chromosomes Cancer 22, 95–99 (1998). Article CAS PubMed Google Scholar Wanschura, S. et al. Regional fine mapping of the multiple-aberration region involved in uterine leiomyoma, lipoma and ...