Domain swapping in MK-Ctd.aStructure of the C-terminal domain of the hyperthermophilic protein MK0293 (MK-Ctd) (PDB ID: 3C19) is shown. Different secondary structural elements, the N-termini and C-termini, and loop1, loop2, and loop3 of MK-Ctd are indicated.bSize exclusion profiles of...
filamentproteinis expressed over its lifetime. Most likely, the different forms of intermediate filaments have subtle but critical differences in their functional characteristics, helping to define the function of the cell. In general, intermediate filaments serve as structural elements, helping cells ...
we report a femtosecond time-resolved X-ray pump/X-ray probe experiment on protein nanocrystals. We observe changes in the protein backbone and aromatic residues as well as disulfide bridges. Simulations show that the latter’s correlated structural dynamics are much slower than expected for the pr...
The two curves disclose the differences between the global modes of the two forms, as also illustrated in Fig. 10. Ligand binding induces both qualitative and quantitative changes in the flexibility of certain structural elements. The arrows in Fig. 9 a indicate the regions whose mobilities were...
Evaluation of the structural elements underlying the two in vitro transfer mechanisms has identified the FABP helix-turn-helix/portal domain as the major determinant of its FA transfer mechanism (2, 8). Protein-membrane interactions are supported by the net positive surface electrostatic potential ...
Common structural elements in ′scorpion-toxin′ type proteins. 来自 jpgmonline.com 喜欢 0 阅读量: 15 作者: Narayanan P 关键词:Amino Acid Sequence Animal Protein Folding Proteins chemistry Scorpion Venoms 年份: 1999 收藏 引用 批量引用 报错 分享 ...
The g-factor spectra of 19 soluble, unconjugated proteins of known structures were measured and used to derive basis spectra, characteristic of the four major structural elements, helix, sheet, turn, and remainder. Using these, the g-factor spectra of other unconjugated proteins, measured in ...
Some biologically active proteins have no well-defined tertiary structure in their native state and are known as intrinsically disordered proteins (IDPs) while other proteins possess structural elements with some disordered (flexible) regions (IDRs)1,2,3. It is well-known that the lack of protein...
By comparative structural analysis of turkey β1-AR complexed with either Gi or Gs, we investigate how a single G-protein-coupled receptor simultaneously signals through two G proteins. We find that, although the critical receptor-interacting C-terminal α5-helices on Gαi and Gαs interact ...
Such modularity can be seen as hierarchical because there are different degrees of integration among its modules. The domain architecture has been shown to harbor evolutionary and structural coherence [9, 29, 38, 89–92]. However, there is also evidence of a sub-domain architecture of protein ...