Key elements of an entropic chemical ligation consist of a chemoselective capture step merging the N and C termini as a covalently linked O/S-ester intermediate to permit the subsequent step of an intramolecular O/S-N acyl shift to form an amide. Many ligation methods exploit the super...
the encoded display of multiple chemical elements on a constant scaffold enabled practical applications, such as fluorescence microscopy procedures or the selective in vivo delivery of payloads to tumours. Furthermore, the versatile structure of the scaffold facilitated the generation of protein-specific ...
This review concentrates on the differences in the effects on indicators of selenium (Se) status of different chemical forms proposed for Se supplementatio... J Nève - 《Journal of Trace Elements in Medicine & Biology》 被引量: 363发表: 1995年 Separation of Selenium-Containing Proteins in Huma...
Nitrogen is one of the most interesting of all chemical elements. It is not a very active element. It combines with relatively few other elements at room temperature. Yet, the compounds of nitrogen are enormously important both in living organisms and in industrial applications. Five of the top...
Scientific Large Language Models: A Survey on Biological & Chemical Domains - GitHub - HICAI-ZJU/Scientific-LLM-Survey: Scientific Large Language Models: A Survey on Biological & Chemical Domains
Majority of biologic drugs and vaccines require temperature-controlled conditions throughout the supply chain to minimize thermal inactivation and contamination, which is costly and impractical. Here, the authors report chemical dispersants that non-covalently solvate proteins within fluorous liquids, resulting...
Table S1. Summary of All Metabolite Binding Proteins Discovered by LiP-SMap and Benchmarking of the Method, Related to Figures 2 and 3 Table S2. Assessment of Overall Data Quality, Related to Figures 3 and S2 Table S3. Euclidean Distances from the Metabolite Binding Sites Measured with LiP-...
The material can be a pure substance, which contains only one chemical component; in this case, the chemical composition corresponds to the relative amounts of the elements constituting the substance. Normally, it can be expressed with a chemical formula. For an example, the chemical formula for...
et al. A general method for the covalent labeling of fusion proteins with small molecules in vivo. Nat. Biotechnol. 21, 86–89 (2003). Article CAS PubMed Google Scholar Gautier, A. et al. An engineered protein tag for multiprotein labeling in living cells. Chem. Biol. 15, 128–136 ...
Targeting proteins to lysosomes with a chemical inducer of arginine methylation Arginine methylation acts as a signal for intracellular proteins to be degraded in lysosomes. We developed methylarginine targeting chimera (MrTAC), a chemical tool that induces proximity with protein arginineN-methyltransferase...