Different regions of RNA molecules can often engage in specific interactions with distinct RNA-binding proteins (RBPs), giving rise to diverse modalities of RNA regulation and function. However, there are currently no methods for unbiased identification
(d) Venn Diagram of the total number of altered microRNAs within MCI and AD groups and the overlap of altered microRNAs between the 2 conditions. Full size image Using a cut-off of 35 cycle threshold (CT), analysis of the OpenArray detected 282 microRNAs in control, 200 microRNAs in MCI ...
To identify the overlap between these EP gene lists and DEGs, we used the "VennDiagram" package. This tool allowed us to visualize the intersections between each EP gene list and the set of DEGs separately. After determining the intersecting genes (EP-DEGs) from both the UniProt and HPA ...
A A Venn diagram is showing unique and shared proteins in all three bait proteins identified under oxidative stress stimuli. B Gene ontology (GO) analysis in the domain of ‘’Biological Process (BP)’’ from ShinyGO webtool, in all three, bait proteins. The significance of the gene ...
Analysis with the TMHMM algorithm revealed that, with an overlap of 22 proteins, 32 and 116 proteins with more than one TMD were identified via the 2D gel and 2D-LC-MS/MS methodologies, respectively (Venn diagram, Figure 2B). The latter methodology clearly improved our ability to detect ...
Venn diagram showing the number of identified proteins in infective larvae (iL3s), the parasitic female (Pf) soluble fraction and the Pf insoluble fraction of Strongyloides venezuelensis Full size image The SignalP analysis detected eukaryotic signal peptides in 110 (20.1%) of the 546 proteins (...
b Four-way Venn diagram of all sample types showing limited overlap between secretomes and proteomes but a relatively closer overlap between proteomes of SIV and in vitro germinated pollen tubes. c Pairwise comparison of sample similarities demonstrates that the secretome of pollen tubes grown ...
The poly-GA associated proteome is distinct from those for poly-GR and -PR. A Venn Diagram showing the overlap between the identified associated proteins for poly-GA, poly-GR and poly-PR dipeptide repeats; B Heatmap of the most enriched GO and KEGG terms in DPR-associated protein sets. Ce...
DNA–protein interactions mediate physiologic gene regulation and may be altered by DNA variants linked to polygenic disease. To enhance the speed and signal-to-noise ratio (SNR) in the identification and quantification of proteins associated with specific DNA sequences in living cells, we developed...
E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015). Article PubMed PubMed Central Google Scholar Szklarczyk, D. et al. The STRING database in 2023: protein–protein association networks and functional enrichment...