Protein-tyrosine phosphatase 1B (PTP1B) is an ubiquitously expressed enzyme that negatively regulates growth-factor signalling and cell proliferation by binding to and dephosphorylating key receptor tyrosine kinases, such as the insulin receptor. It is unclear how the activity of PTP1B is regulated...
Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signalling pathways, including direct negative regulation of classic insulin and leptin signalling pathways, and is implicated in the pathogenesis of several cardiometabolic diseases and cancers....
The aim of our work was to study the role of the protein-tyrosine phosphatase 1B (PTP1B) on the cellular responses to TGF-β, using for this purpose immortalized neonatal hepatocytes isolated from both PTP1B+/+ and PTP1B−/− mice. We have found that PTP1B deficiency conferred ...
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Protein tyrosine phosphatase 1B (PTP1B) is a key molecule in modulating low-degree inflammatory conditions such as diabetes. The role of PTP1B in other chronic inflammations, however, remains unknown. Here, we report that PTP1B deficiency ameliorates Dextran Sulfate Sodium (DSS)-induced murine...
Compounds 1–2 possessed inhibitory activity on PTP1B enzyme with IC50 values of 26.1 ± 0.7 and 13.3 ± 0.4 μM, respectively. Ursolic acid was used as positive control showing an IC50 value of 3.5 ± 0.2 μM in this assay. This result reveals that these 9,10゛nthraquinones might be...
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The insulin receptor is a substrate for PTP1B (18, 19, 20), T-cell protein-tyrosine phosphatase (21, 22), and PTPϵ (23) among others. In vitro studies suggest that the EGFR is a substrate for PTP1B, T-cell protein-tyrosine phosphatase, receptor-type protein-tyrosine phosphatase, ...
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Gab1) in the retina Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retinaProtein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retinaAdapter prote...