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Protein tyrosine phosphatase-1BRetinal degenerationRhodopsinNeuroprotectionProtein tyrosine phosphatase 1B (PTP1B) is considered as a major negative regulator of insulin receptor (IR) signaling. IR signaling in retina has been demonstrated to be neuroprotective. Photoreceptor-specific deletion of PTP1B ...
Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signalling pathways, including direct negative regulation of classic insulin and leptin signalling pathways, and is implicated in the pathogen
Protein Tyrosine Phosphatase 1B (PTP1B)荧光法(人源)检测试剂盒内包含了Protein Tyrosine Phosphatase 1B (PTP1B)荧光法(人源)检测所需的所有试剂和相关组份。简单快捷的方案设计和优化的试剂配比,为全球科研工作者提供最优的Protein Tyrosine Phosphatase 1B (
Protein tyrosine phosphatase 1B (PTP1B) is a key molecule in modulating low-degree inflammatory conditions such as diabetes. The role of PTP1B in other chronic inflammations, however, remains unknown. Here, we report that PTP1B deficiency ameliorates Dextran Sulfate Sodium (DSS)-induced murine...
INTRODUCTION Protein tyrosine phosphatase 1B (PTP1B) is primarily known to negatively regulate insulin receptor signaling, with Ptp1b À / À mice displaying hypersensitivity to insulin.1 PTP1B regulates several other receptors, such as the Ephrin receptor, Toll-like receptor (TLR) signaling, ...
1. Objective: To study the protein tyrosine phosphatase-1B(PTP1B) inhibitory activity of natural products from algae aiming at searching for new way for the treatment of type 2 diabetes mellitus(T2DM) and obesity. 目的:通过对海藻天然产物进行活性筛选,寻找蛋白酪氨酸磷脂酶1B(PTP1B)抑制剂,为...
The protein-tyrosine phosphatase 1B (PTP1B; PTPN1) is an important regulator of mammalian metabolism and also helps control signaling by growth factors, cytokines, and extracellular matrix. Gene knockout studies in mice established PTP1B as a key negative regulator of the insulin and leptin rece...
Correction: Deletion of Protein Tyrosine Phosphatase 1B (PTP1B) Enhances Endothelial Cyclooxygenase 2 Expression and Protects Mice from Type 1 Diabetes-Induced Endothelial Dysfunction doi:10.1371/journal.pone.0130781DELETION mutationPROTEIN-tyrosine phosphataseCYCLOOXYGENASE 2GENE ...
Protein tyrosine phosphatase 1B (PTP1B) has been shown to be involved in the negative regulation of both insulin and leptin action at the in vitro, ex vivo and in vivo levels. A growing body of human genetic data also support the hypothesis that PTP1B has an important role in insulin ...