The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).スコットディラーセン...
英文别名1,1,1-trifluoro-N-[4-[2-[4-[2-[4-(trifluoromethylsulfonylamino)phenyl]propan-2-yl]phenyl]propan-2-yl]phenyl]methanesulfonamide | Protein Tyrosine Phosphatase Inhibitor IV 规格或纯度≥98% 英文名称PTP Inhibitor IV 生化机理PTP Inhibitor IV 是一种蛋白酪氨酸磷酸酶 (PTP) 抑制剂,可竞争...
4) tyrosine kinase inhibitor 酪氨酸蛋白激酶抑制剂 1. Objective To assess the effect of tyrosine kinase inhibitor (2,5-MC) on the inhibition of in-stent inti-mal hyperplasia. 目的评估酪氨酸蛋白激酶抑制剂2,5-MC抑制支架植入术后内膜增殖的效果。 更多例句>> 5) Protein tyrosine kinase inhibitor...
Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal function is essential for maintaining normal cell growth and differentiation. However, aberrant activation of PTKs caused by v...
having one of the following formulae (II) to (IV), wherein R′ is H or C-Calkyl; or an enol tautomer of a compound of formula (I) in which any of the groups R or R′ is hydrogen; in the manufacture of a medicament for use as a protein tyrosine phosphatase (PTP) inhibitor. ...
F. et al. Structure based design of a low molecular weight, non-phosphorous, non-peptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J. Biol. Chem. 275, 10300–10307 (2000).This paper describes the structure-based design of PTP1B inhibitors. CAS PubMed Google ...
Solubility: Soluble to 100 mM in DMSO Purity: ≥98% Storage: Store at +4°C CAS No: 345630-40-2 The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless state...
Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human diseases, such as cancers, diabetes, autoimmune disorders, and neurol
蛋白酪氨酸磷酸酶1B(protein tyrosine phosphatase,PTP1B)是第一个被成功分离的人蛋白质酪氨酸磷酸酶(Protein Tyrosine Phosphatase PTP),它是蛋白酪氨酸磷酸酶家族中的一个经典的非受体型酪氨酸磷酸酶,在胰岛素信号通路中起着重要的负调控作用,是目前公认的一个新颖的糖尿病和肥胖症治疗靶点。 3. Studies show tha...
Protein tyrosine phosphatase inhibitor, preparation method and uses thereof 发明人: Luo Duqiang;Zhang Jun;Liu Zhiqin 申请人: 申请日期: 2013-05-07 申请公布日期: 2017-12-26 代理机构: Harness, Dickey & Pierce, P.L.C. 代理人: Heibei University 地址: CN 摘要: Disclosed in the present invent...