PTEN 蛋白激酶通过脂质磷酸酶功能抑制磷脂酰肌醇-3-激酶 (PI3K) 的活性，被确定为重要的肿瘤抑制因子。除此之外，在酪氨酸磷酸酶 (protein tyrosine phosphatases, PTPs) 家族中发现了一些潜在的肿瘤抑制因子，包括 DEP1，PTPκ，PTPρ 以及 PTPγ 等。出人意料的是由PTPN11 基因编码的 SHP2 蛋白的激活会增加肿...
The effects of inhibitors of a series of serine-threonine phosphatases, i.e., okadaic acid (which suppresses PP1 and PP2A phosphatase activities), endothall (PP2A), cyclosporin A and cypermethrin (PP2B), CCT007093 (PPM1D), and dephostatin (blocks tyrosine phosphatases), on the depression ...
The eukaryotic protein kinases that directly phosphorylate proteins are divided into two major classes: those that phosphorylate tyrosine and those that ph... SS Taylor,E Radzio-Andzelm,T Hunter - 《Faseb Journal》 被引量: 468发表: 1995年 Serine/Threonine Protein Kinases and Phosphatases in Filame...
Protein serine/threonine phosphatases areenzymesthat reverse the actions ofprotein kinasesby cleaving phosphate fromserineandthreonineresidues in proteins. They are structurally distinct from the superfamily ofprotein phosphatases, which encompasses thetyrosineand dual specificity (tyrosine and serine/threonine) ...
tyrosine andserinekinases havelipidinteraction domains such as PH, 38 have domains linked tosmall GTPasesignaling, and 28 serine kinases have domains linked tocalcium signaling. Most members of a protein kinase family have the same set of ancillary domains, but there are some exceptions, and ...
SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase. J Biol Chem. 2017;292:19890–904. Article CAS PubMed PubMed Central Google Scholar Pirola L, Zerzaihi O, Vidal H, Solari F. Protein acetylation ...
Since CjWRKY1 contains nine tyrosine residues except for Y115, additional experiment is needed to study the involvement of other tyrosine residue(s) in the phosphorylation and the regulation of WRKY activity. On the other hand, several groups have reported that serine/threonine phosphorylation of ...
When a cocktail of broad-spectrum tyrosine phosphatase inhibitors was applied, channel activation was completely abolished, whereas inhibitors of serine/threonine protein phosphatases had no effect. On the other hand, protein tyrosine kinase inhibitors brought the channel out of an inactivated state. In...
(Pickrell and Youle, 2015). Parkin is itself regulated by post-translational phosphorylation, ubiquitylation, nitrosylation, and sulfhydration. Phosphorylation of parkin by nonreceptor tyrosine kinase c-Abl (Ko et al., 2010), casein kinase-1 (Rubio de la Torre et al., 2009;Yamamoto et al., ...
Serine (Ser, 105) 2.2 9.2 — Threonine (Thr, 119) 2.6 10.4 — Tryptophan (Trp, 204) 2.4 9.4 — Tyrosine (Tyr, 181) 2.2 9.1 1.01 9.6–10.0 Valine (Val, 117) 2.3 9.6 — TABLE 1.3. One-Letter Notation of Amino Acidsa 1-Letter3-Letter1-Letter3-Letter A Ala M Met B Asx ...