Interestingly, for plants, the only candidates qualifying as potential TTL homologs are the tubulin tyrosine ligase-like 12 proteins. To get insight into the biological functions of these potential TTL homologs, we cloned the rice TTL-like 12 protein(Os TTLL12)andgeneratedoverexpression Os TTLL12-...
The phosphorylation/dephosphorylation of proteins plays a key role in most cellular processes such as signal transduction, proliferation, and growth as many enzymes and receptors are activated and deactivated via phosphorylating/dephosphorylating events performed by kinases/phosphatases. In the normal cells,...
We found that the p13suc1 complex also contained cytoskeletal proteins such as MAP2 and neurofilaments, but their phosphorylation levels were not different. These results indicate that RPTPγ and PTPζ have different substrate specificities, and RPTPγ inhibits NGF-induced neurite outgrowth of PC12D...
Such RPTPα dimers could be activated by extracellular ligands or intracellular binding proteins that induce monomerization or by intracellular signaling events that induce an open conformation of the dimer. 展开 DOI: 10.1128/MCB.20.16.5917-5929.2000 ...
Overall, this workidentif i ed compound 19h as a new ROR1 inhibitor, providing a novel leadcompound for the treatment of lung cancer and breast cancer.■INTRODUCTIONAs a class of transmembrane proteins, receptor tyrosine kinases(RTKs) play essential roles in cellular physiological processessuch ...
The receptor-like protein tyrosine phosphatases (PTPR) are transmembrane proteins and nearly all contain a tandem phosphatase domain, D1 and D2, both of which express the catalytic signature motif. From: Signal Transduction (Third Edition), 2016 ...
The proteins soluble fms-like tyrosine kinase (sFlt)-1, placental growth factor (PlGF), and plasminogen activator inhibitor (PAI)-2, and the B vitamin folate are determinants of placental development. This study aims to identify associations between these maternal biomarkers and early fetal size. ...
OBJECTIVE: To estimate whether alterations in plasma levels of the proangiogenic proteins placental growth factor (PlGF) and vascular endothelial growth fa... AK Wikstr?M,A Larsson,UJ Eriksson,... - 《Obstetrics & Gynecology》 被引量: 679发表: 2007年 Soluble fms-Like Tyrosine Kinase 1 (sFlt1...
3.1.4 Iron binding proteins Compared to normal cells, cancer cells differ in the expression and/or activity of many iron-related proteins, proved to play a role in tumor initiation, proliferation, and metastasis. Due to their contribution in maintaining relatively high i...
2020, Molecular Biology and Evolution Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats 2020, Clinical Science View all citing articles on ScopusView full text © 2018 Published by Elsevier Ltd. ...