Therefore, GnRHR represents a potential target for GnRH-analogs used for cancer treatment. Interestingly, the signaling mechanism of the GnRHR in other ... S Kraus,Z Naor,R Seger - 《Archives of Medical Research》 被引量: 295发表: 2001年 17β-Estradiol Stimulates the Growth of Human Keratin...
The Tetraspanins (Tspan) protein family, also known as the tetraspanin family, contains 33 family members that interact with other protein molecules such as integrins, adhesion molecules, and T cell receptors by forming dimers or heterodimers. The Tspan
Protein degraders have several potential advantages over small-molecule inhibitors that have traditionally been used for cancer treatment, including their event-driven (rather than occupancy-driven) pharmacology, which permits sub-stoichiometric drug concentrations for activity, their capacity to act ...
-target toxicities. Occupancy-based inhibitors implicitly rely upon high binding affinity and are thus vulnerable to point mutations involving the drug binding site [11,12]. In many cases, the application of cancer treatment is what drives loss of the ligand binding site or point mutations which ...
Cancer treatment can be tough on the body, but for the patient to survive the cancer, it's often necessary to go through with the treatment anyway.
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attentio
Methods are disclosed for treating cancer and inhibiting tumor growth by administering to a mammal in need thereof a therapeutically effective amount of 3-[-1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-indol-3-yl)-1H-pyrrole-2,5-dione, or a pharmaceutically acceptable salt or solvate thereof.收...
"This study explains why very early liver cancer can still spread to the entire body one to three months after surgery. It is of great value for future drug research, and helps explain the biological features of liver cancer so that more effective treatment can be selected." said Fan Jia,...
When the pharmaceutical industry develops new medicines – for example for cancer treatment – it is important to have detailed knowledge of the body's molecular response to the medicine. "With a better knowledge of the many complex processes which are activated in connection with illness and ...
Additionally, the first oral PROTACs (ARV-110 and ARV-471) have shown encouraging results in clinical trials for prostate and breast cancer treatment, which inspires a greater enthusiasm for PROTAC research. Here we focus on the structures and mechanisms of PROTACs and describe several classes of...