We have shown that CRP positively affects collagen-induced arthritis development and progression. In order to thoroughly address the question, we have also reported a mechanism by which CRP may be exerting its influence on the system, through modulation of dendritic cells, which potently modulate T...
et al. Expression level of integrin alpha 5 on tumour cells affects the rate of metastasis to the kidney. Br. J. Cancer 88, 327–333 (2003). 25. Stupack, D. G., Puente, X. S., Boutsaboualoy, S., Storgard, C. M. & Cheresh, D. A. Apoptosis of adherent cells by recruitment...
Thus, a single mutation in porin that negatively affects the targeting might be expected to be followed by a compensatory event in the same region. Following interactions with the Tom20, porin is passed through the Tom40 pore, to interact with the Tim9–Tim10 and Tim8–13 complexes of the...
A. Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat interactions with both cyclin T1 and the Tat transactivation region. J. Virol. 81, 4226–4234 (2007). CAS PubMed PubMed Central Google Scholar Fulcher, A. J. et al. The protein...
An inflammatory disease that affects the conjunctiva, sclera, and episclera (the connective tissue between the conjunctiva and sclera). It is associated with underlying systemic diseases such as Wegener’s granulomatosis or rheumatoid arthritis in about half of the cases. ...
2022). It remains to be investigated how this modulation of the CCN protein TSP1 domain affects their function. TSP1 type I repeat functions Identifying the vast thrombospondin 1 interactome from mining manually curated databases of protein–protein-interactions and validating the results by Resovi ...
Background: Borna disease virus (BDV) is the etiological agent of a rare progressive meningoencephalitis that affects mostly horses and sheep. There is an ... SA Hajjar,H Baksh - 《Journal of Clinical Virology》 被引量: 0发表: 2006年 Protein S acquired deficiency Background. With a few ...
Notably, the phosphorylation status also affects GRK2 stability in a cell cycle context, thus governing the fluctuations in kinase levels taking place during cell cycle progression. Phosphorylation of GRK2 at Ser670 by CDK2–cyclin A and the subsequent binding of the prolyl-isomerase Pin1, are ...
affects T cell and B cell differentiation71,73. IL6 acts directly on neutrophils, essential mediators of inflammation and joint destruction in RA, through membrane-bound IL6R71. Experiments on fibroblasts isolated from the synovium of patients with RA show that anti-IL6 antibodies prevented ...
Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. Therefore, targeting PPIs is a d