Results showed that stearate induced DNA damage and cancer cell death, while oleate reduced these effects. The researchers concluded that dietary stearate could suppress tumor growth, especially when combined with inhibitors of fatty acid conversion. Future research could explore dietary interventions as ...
NF-κB activation results in the transactivation of a multitude of responsive genes which contribute to the inflammatory phenotype of arthritis, including TNF-α from macrophages, MMPs from synovial fibroblasts and chemokines that recruit immune cells to the inflamed pannus [11]. ...
affinity ligand itself may be recognized as a substrate by the E3. Therefore, the researchers proposed that the AdPROM system can be modified by exclusively replacing the aGFP with smaller binders that bind to specific endogenous proteins. They chose a class of synthetic polypeptides called monobod...
Smoking increases the risk of developing rheumatoid arthritis (RA) and worsens the course of the disease. In the current study we analysed whether smoking can affect gene expression directly in the joints.Synovial fibroblasts were incubated with 5% cigarette smoke extract and changes in gene expressio...
One woman with dry mouth (xerostomia) and debilitating arthritis was also given cod liver oil as an experiment: “The treatment has been continuous during these years and she has been practically free from arthritis.” In a group of 78 patients with cavities, the m...
One woman with dry mouth (xerostomia) and debilitating arthritis was also given cod liver oil as an experiment: “The treatment has been continuous during these years and she has been practically free from arthritis.” In a group of 78 patients with cavities, the most severe ca...
25, 26, 27, 28, 29, 30, 31 The important role of neutrophils in ischemia/reperfusion injury raises the possibility that tissue injury could be prevented by inhibiting neutrophil recruitment to the ischemic tissue through inhibition of chemokines that direct neutrophil infiltration into the tissue. ...
Objectives Smoking increases the risk of developing rheumatoid arthritis (RA) and worsens the course of the disease. In the current study we analysed whether smoking can affect gene expression directly in the joints. Methods Synovial fibroblasts were incubated with 5% cigarette smoke extract and chan...
The pharmacological activation of Rev-erbα with SR9009 demonstrates significant potential by improving functional outcomes and reducing detrimental inflammatory and oxidative responses; conversely, its inhibition with SR8278 worsens these effects (Figure 10). In summary, these findings suggest that targeting...
I. (2022). Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis. International Journal of Molecular Sciences, 23(1), 481. https://doi.org/10.3390/ijms23010481 Note that from the first issue of 2016, ...