Quantification of mRNA and protein expression of TAP1 and MHC class I molecule during T. cruzi infection.Ricardo CamargoLiliam O. FariaAlexander KloßCecília B. F. FavaliUlrike KuckelkornPeterMichael KloetzelCézar Martins de SáBeatriz D. Lima...
1. Correlation between TAP protein and astrocytoma; 抗原处理相关转运蛋白和星形细胞瘤的相关性研究2) Transporters associated with antigen processing 抗原处理相关蛋白3) TAP1 抗原处理相关转运体1 1. Expression and correlation of TAP1 and MHC-I molecules in condyloma acuminatum lesions; 抗原处理相关...
There, the peptides assemble with class I major histocompatibility complex (MHC) molecules for presentation to cells of the immune system [5]. TAP1 and TAP2 are members of the ABC family and are each a ‘half transporter’, consisting of a membrane-spanning domain (with six transmembrane ...
et al. Lateral diffusion of GFP-tagged H2Ld molecules and of GFP–TAP1 reports on the assemby and retention of these molecules in the endoplasmic reticulum. Immunity 11, 231–240 (1999).Characterizes the effect of the formation of large protein complexes of TAP and MHC class I in the ER...
We show that maleylation of OVA enhanced its presentation to an OVA-specific MHC class I-restricted T cell line by both macrophages and B cells. This enhanced presentation involved uptake through receptors of scavenger receptor (SR)-like ligand specificity, was TAP-1-independent, and was ...
外源性抗原优先进入主要组织相容性类II(MHC-II)途径以启动CD4+ T细胞。然而,以前的研究表明,颗粒状的VLPs可以被APCs成功摄取并通过交叉呈现进入MHC-I途径。通过与抗原处理相关的转运蛋白(TAP)独立的内体途径或TAP依赖的内体至细胞质途径可以实现MHC-I的装载。将VLPs与APCs的刺激因子结合使用可以产生CTL和TH1反应。在...
蛋白别名: ABC transporter, MHC 1; Antigen peptide transporter 1; AOI; APT1; ATP-binding cassette sub-family B member 2; ATP-binding cassette, sub-family B (MDR/TAP), member 2; beta-filamin; DAAP-57C1.5; FH1; filamin homolog 1; filamin-3; filamin-B; FLJ26666; FLJ41500;...
We show that maleylation of OVA enhanced its presentation to an OVA-specific MHC class I-restricted T cell line by both macrophages and B cells. This enhanced presentation involved uptake through receptors of scavenger receptor (SR)-like ligand specificity, was TAP-1-independent, and was ...
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This leads to decreased expression of TAP1 through interaction between miR-346 and the TAP1 3′-UTR. TAP1 is an ATP-binding cassette transporter that translocates antigens derived from proteasomal processing into the ER lumen for loading onto MHC antigen receptors. Notably, miR-346 also ...