1CREB-binding protein structure and function 1.1CBP gene and protein structure CREB binding protein (CBP) is encoded by a 190kb gene located on chromosome 16p13.3. Transcription yields a 7.3kb mRNA, which is translated into a protein of 2442amino acidresidues in humans[1,2]. The majorprotein...
Deciphering the relationship between a gene and its genomic context is fundamental to understanding and engineering biological systems. Machine learning has shown promise in learning latent relationships underlying the sequence-structure-function paradig
While protein structure and function is dynamic and context-dependent (e.g. on cellular state, other molecules and PTMs), it is still defined by the underlying amino-acid sequence. This means that from an information-theory perspective, the protein’s information (e.g. its structure) is ...
An investigation of both α- and β-amino acid peptides, and hybrids of both, as inhibitors of the BH3–BCL-X L interaction. CAS PubMed Google Scholar Fletcher, S. & Hamilton, A. D. Protein surface recognition and proteomimetics: mimics of protein surface structure and function. Curr....
Protein structural data has increased exponentially, such that fast and accurate tools are necessary to access structure similarity search. To improve the search speed, several methods have been designed to reduce three-dimensional protein structures to
The accurate delineation of protein domain boundaries is an important step for the prediction of protein structure, function, evolution and design. Since a single domain spans an entire polypeptide chain or a subunit of such a chain, domains provide one of the most useful sources of information ...
From sequence to function through structure: deep learning for protein design Noelia Ferruz, Michael Heinzinger, Mehmet Akdel, Alexander Goncearenco, Luca Naef, Christian Dallago bioRxiv 2022.08.31.505981/Computational and Structural Biotechnology Journal Volume 21, 2023 • Supplementary • accompanying...
Using the link structure of a network to gain insight into the function of its nodes is a ubiquitous technique in biological, social, and computer networks [1–11]. For example, Kleinberg used the link structure of the Internet to give each node a hub and an authority index [9], and Br...
functiond. It starts with a connected set ofnvertices randomly picked on the graph and proceeds by “moving” selected nodes along the edges of the graph to maximized. Moves are accepted according to Metropolis criteria. In [11], the comparison of MC and SPC algorithms have been done, and ...
structure, and then construct a sequence of subgraphs, where each subgraph is a subset of the next one. They then define a permutation-invariant descriptor function for each subgraph that is related to curvature. This function is designed to be invariant to the order in which the nodes are ...