SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformationGrowth factor signallingOncogenesKIT is a receptor tyrosine kinase (RTK) involved in several cellular processes such as regulation of proliferation, survival and differentiation of early ...
SRC-like adaptor protein 2 (SLAP2) binds to wild-type KIT in a ligand-dependent manner and is furthermore found constitutively associated with the oncogenic mutant KIT-D816V. Peptide fishing analysis mapped pY568 and pY570 as potential SLAP2 association sites in KIT, which overlaps with the ...
The importance of this on/off switch-like function, in the context of cancer, is perhaps best illustrated by the resistance to small-molecule inhibitors caused by mutation of a gatekeeper threonine to a bulkier hydrophobic residue in the active site of the c-Abl, c-SRC, PDGFR and EGFR ...
Another stand-alone GLA-containing protein intimately connected with hemostasis is Protein S—which contains an N-terminal GLA domain followed by four EGF domains and ending in two Laminin-G like domains (2) “Non-GLA proteases”: These proteolytic enzymes do not have a GLA domain. There are ...
84 As compared to agonists which facilitate G protein and β-arrestin signaling at the same time, a β-arrestin-biased agonist for δ-opioid receptor can effectively control anxiety-like behaviour by activating ERK1/2 in the limbic structures of the brain.85 Hence, identifying therapeutic ...
产品名称: Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN 中文名称: WRN重组蛋白 别名: (DNA helicase, RecQ-like type 3)(RecQ3)(Exonuclease WRN)(RecQ protein-like 2) 纯度: G
Protein phosphorylation is recognized as the primary mechanism for the transduction of extracellular stimuli into intracellular events (Cohen, 1982; Nestler et al.,1984). Ineukaryotes, for example, all of the biochemical actions of cAMP have been attribu
calculating the overlap score of the blast result. To overcome this problem the token_score_overlap_score_weight has to be set to 0.0. Therefore the other two scores have to be raised. These three parameters have to sum up to 1. The resulting parameter configuration could look like this: ...
The format of prothint_augustus.gff in this mode looks like this: 2R ProtHint intron 11506230 11506648 4 + . src=M;mult=4;pri=4 2R ProtHint intron 9563406 9563473 1 + . grp=69004_0:001de1_702_g;src=C;pri=4; 2R ProtHint intron 8446312 8446371 1 + . grp=43151_0:001cae_473...
(Fig.2). Other notable structural determinant includes the acidic C-terminal and x-linker (connecting a′ and b′-domains). The TRX-like domain is typically categorized as harboring the a-type (catalytic) and b-type (non-catalytic) domains, whereby the a′ and b′ symbols are often used...