SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformationKIT is a receptor tyrosine kinase (RTK) involved in several cellular processes such as regulation of proliferation, survival and differentiation of early hematopoietic cells, germ cells and ...
SRC-like adaptor protein 2 (SLAP2) binds to wild-type KIT in a ligand-dependent manner and is furthermore found constitutively associated with the oncogenic mutant KIT-D816V. Peptide fishing analysis mapped pY568 and pY570 as potential SLAP2 association sites in KIT, which overlaps with the ...
Figure 2.Phosphoregulation of GABAAR endocytosis. The endocytosis of GABAARs is regulated by the interaction of the AP2 complex with β and γ2 subunits. Phosphorylation of β3 (S408/S409) and γ2 (Y365/Y367) by PKA/PKC and Src/Fyn, respectively, prevents binding to AP2 and thus stabi...
Another stand-alone GLA-containing protein intimately connected with hemostasis isProtein S—which contains an N-terminal GLA domain followed by four EGF domains and ending in two Laminin-G like domains (2) “Non-GLA proteases”: Theseproteolytic enzymes (a)...
Like aPKCι/λ, the membranes contained a negligible amount of β-COP that was reflected by the drastic reduction in Rab2-dependent vesicle formation. These data suggest that Src-mediated tyrosine phosphorylation of aPKCι/λ facilitates aPKCι/λ association with Rab2-Src-GAPDH on VTCs, ...
产品名称: Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN 中文名称: WRN重组蛋白 别名: (DNA helicase, RecQ-like type 3)(RecQ3)(Exonuclease WRN)(RecQ protein-like 2) 纯度: G
This protein class shares a common NTF2-like domain which, in case of G- members, localizes to the periplasm of the respective host47. In contrast, TraH resisted proteolytic degradation in protease protection assays using E. faecalis protoplasts, suggest- ing a reversed topology where the C-...
Protein phosphorylation is recognized as the primary mechanism for the transduction of extracellular stimuli into intracellular events (Cohen, 1982; Nestler et al.,1984). Ineukaryotes, for example, all of the biochemical actions of cAMP have been attribu
The format of prothint_augustus.gff in this mode looks like this: 2R ProtHint intron 11506230 11506648 4 + . src=M;mult=4;pri=4 2R ProtHint intron 9563406 9563473 1 + . grp=69004_0:001de1_702_g;src=C;pri=4; 2R ProtHint intron 8446312 8446371 1 + . grp=43151_0:001cae_473...
(Vargas et al., 1997). The tail domain ofEhMyoIB contains three characteristic regions found in myosin I — a putative membrane-binding domain, a very short domain rich inalanineandprolinedemonstrated to be functional for actin-binding and src-homology three domains (Vargas et al., 1997). ...