Using PGAP-controlled gene expression, NRRL Y-11430 has somewhat more host cell proteins in its culture supernatant and grows to a lower cell culture density (in shake flasks) compared with the type strain. We hypothesize that both observations are related and due to slightly increased cell lysis...
Our structural and infection assays indicate an important role of the whole multimodular protein allowing both to locate CbpL at specific places on the cell wall and to interact with host components in order to facilitate pneumococcal lung infection and transmigration from nasopharynx to the lungs ...