生物领域的下游任务/实验 PPI Protein-proteinInteraction 在OntoProtein和BioBridge,KeAP中都做了这个实验,一开始感觉很难理解所以专门去看了一些文献。 STRING数据集,使用GNN学习Protein-protein Interaction Learning Unknown from Correlations: Graph Neural Network for Inter-novel-protein Interaction Prediction 贡献1 ...
蛋白质-蛋白质相互作用(protein-protein interaction,PPI)是指两个或两个以上的蛋白质分子通过非共价键形成蛋白质复合体(protein complex)的过程。研究蛋白之间的相互作用网络,有助于挖掘核心的调控基因,目前已经有很多的蛋白质相互作用的数据库,在这里,...
STRING database (Search Tool or the Retrieval o Inter- acting Genes/Proteins) is dedicated to such unctional asso- ciations between proteins, on a global scale. Protein–protein interaction in ormation can already be retrieved roma number o online resources. First, primary ...
Interaction experiments: How protein interactions are defined and measuredlarsjuhljensen 立即播放 打开App,流畅又高清100+个相关视频 更多52 -- 5:55 App The STRING database: Protein networks and how they are made 8 -- 5:45 App Arena3D: Browser-based 3D layout of multilayer networks 26 -- ...
基因产物的互作就普遍了,那就是蛋白互作,也就是STRING等数据库里收集的信息。 蛋白互作也容易直观理解些,复杂的多细胞生命体,几乎所有的功能都是靠蛋白来实现的,所以有很多蛋白要互相结合(空间上)在一起来行使自己的功能。 --- 还有一个就是遗传学领域的基因互作,这与生物学的基因互作完全不同,遗传学考虑的是...
A protein-protein interaction network stores the information about the protein-protein interactome of a given organism, that is the whole set of its protein-protein interactions. Even if it has been suggested that the size of protein-protein interactomes proportionally grows with the biological comple...
applied this pipeline to the 19 human pathogens listed in Supplementary Table2. To monitor the performance of our pipeline, we assembled a set of positive controls and an ~700-fold larger negative set based on information from the STRING protein-protein interaction database (Supplementary Methods)...
STRING数据库https://string-db.org/ 选择多靶点分析,便可以将交集靶点上传上去。 这里我随便选了一小部分的gene,仅用于测试。 会提供相当多的信息 相互作用类型或者预测的相互作用 还可以根据需要调整设置选项 置信度最好选择高一些。 通过选择多层联系的互作蛋白,可以扩充PPI网络。
Protein-proteinInteractionsOutlineIntroductionTheStudyofProtein-proteinInteractionbyMassSpectrometryYeast-Two-HybridPhageDisplayProt..
Protein-Protein Interaction NetworksFunctional Enrichment Analysis Welcome to STRING Protein-Protein Interaction Networks Functional Enrichment Analysis Organisms 12535 Proteins 59.3 mio Interactions >20 bln Search