蛋白质-蛋白质相互作用(protein-protein interaction,PPI)是指两个或两个以上的蛋白质分子通过非共价键形成蛋白质复合体(protein complex)的过程。研究蛋白之间的相互作用网络,有助于挖掘核心的调控基因,目前已经有很多的蛋白质相互作用的数据库,在这里,...
Protein–protein interaction networks are the networks of protein complexes formed by biochemical events and/or electrostatic forces and that serve a distinct biological function as a complex. The protein interactome describes the full repertoire of a biological system’s protein–protein interactions (PPI...
STRING v9. 1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res, 41(D1), D808-D815.Franceschini, A., Szklarczyk, D., Frankild, S., Kuhn, M., Simonovic, M., Roth, A., et al. (2013). STRING v9. 1: protein-protein interaction ...
根据数据类型,ppi预测方法分类为:genomic data, protein sequence, protein structure, PPI networks, gene expression, and annotations of gene function, localization, and process。基于genomic data数据分析conserved operon structure, fusion domains, phylogenetic profiles, and interologs。 很多研究基于蛋白质序列预...
Explore advanced protein-protein interaction detection services, including Yeast Two-Hybrid, BLI, CO-IP, and GST pull-down, designed for qualitative and quantitative analysis.
Perturbations to the protein﹑rotein interaction networks (PPIN) present in neurons, glia and other cell‐types has been linked to multifactorial neurological disorders. Yet while knowledge of brain PPINs is steadily improving, the complexity and dynamic nature of the heterogeneous central nervous ...
proteininteraction蛋白质networkslectures讲座 Protein-proteininteraction networks FunctionalGenomics RolandKrause roland.krause@molgen.mpg.de 1 Protein-Proteininteractions 1. Experimentalmethods(today) 2. Modulesandcomplexes 3. Networkevolution? 2 Protein-proteininteractions Experimentalapproaches 3 4 Contents...
1.The protein-protein interaction network is a valuable tool to investigate the molecular networks underlying a living cell.2000年酵母大规模蛋白质相互作用网络图谱的成功描绘,蛋白质相互作用特别是大规模蛋白质相互作用研究成为生命科学领域的又一个研究热点。 2.Several representative methods of clustering in ...
There are a multitude of methods that have been proposed to detect protein-protein interactions and populate protein-protein interaction networks. In general, none of them is better than the others but each method has its own strengths and weaknesses. The goodness of a method is measured in ter...
Path lengths in protein-protein interaction networks and biological complexity We investigated the biological significance of path lengths in 12 proteinprotein interaction (PPI) networks. We put forward three predictions, based on the... X Ke,I Bezakova,L Bunimovich,... - 《Proteomics》 被引量:...