EltonZeqiraj,Daan MFvan Aalten, inCurrent Opinion in Structural Biology, 2010 Introduction Protein kinasesare involved in orchestrating almost all aspects of cellular life by integratingcell signallingnetworks. A myriad of studies have described the molecular basis of protein kinase function. The first...
Twitter Google Share on Facebook microtubule (redirected frommicrotubule-associated protein (MAP) kinase) Thesaurus Medical Encyclopedia mi·cro·tu·bule (mī′krō-to͞o′byo͞ol, -tyo͞o-) n. Any of the cylindrical hollow tubulin-containing structures that are found in the cytoplasm, cili...
WantingJiao,Emily J.Parker, inAdvances in Protein Chemistry and Structural Biology, 2012 BAllsoteric Signaling in Protein Kinase A Protein kinaseis a family ofenzymesthat catalyzes the transfer of a phosphate group from ATP to a protein or peptide substrate. This phosphorylation usually results in ...
A resource on protein kinases, a key class of regulatory proteins. Includes genomic and evolutionary analyses (kinomes), classification, disease associationa and an extensive database of protein kinase genes.
Phenylephrine (PHE), an α1 adrenergic receptor agonist, increases phospholipase D (PLD) activity, independent of classical and novel protein kinase C (PKC) isoforms, in rat-1 fibroblasts expressing α1A adrenergic receptors. The aim of this study was to
Protein kinase D (PKD) has been implicated in a wide range of cellular processes and pathological conditions including cancer. However, targeting PKD therapeutically and dissecting PKD-mediated cellular responses remains difficult due to lack of a potent and selective inhibitor. Previously, we identified...
et al. Mutational dissection of the S/T-kinase StkP reveals crucial roles in cell division of Streptococcus pneumoniae. Mol. Microbiol. 83, 746–758 (2012). Article CAS PubMed Google Scholar Stein, E. A., Cho, K., Higgs, P. I. & Zusman, D. R. Two Ser/Thr protein kinases ...
Optimizing the production of recombinant proteins is a problem of major industrial and pharmaceutical importance. Secretion of the protein by the host cell considerably simplifies downstream purification processes. However, for many proteins, this is als
We propose InSite, a computational method that integrates high-throughput protein and sequence data to infer the specific binding regions of interacting protein pairs. We compared our predictions with binding sites in Protein Data Bank and found signific
In addition, PEBP1, also known as Raf kinase inhibitory protein (RKIP), was downregulated in sEVs of bladder cancer patients in this study. It may act as a metastasis-suppressor gene through the regulation of important signaling cascades, i.e., the RAF-MEK-ERK kinase cascade, G protein-...