protein kinaseoncogenetransgenic micelymphomaProtein kinase CK2 (casein kinase II) is a serine-threonine protein kinase with a wide range of substrates, many of which are involved in cell cycle regulation. CK2 activity is elevated in a variety of human tumors and we have used a transgenic mouse...
Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells. Previously, we reported that high PKCK2 activity could protect cells from receptor-mediated through of procaspase-2. Because anoikis is another form of , w... H Ko,S Kim...
Casein kinaseⅡ(CK2) is a highly conserved and messenger-independent serine/threonine protein kinase with both cytosolic and nuclear localization in eukaryotes cells.The holoenzyme is generally composed of two catalytics(α and/or α′)...
The abbreviations used are: MAPK, mitogen-activated protein kinase; APC, adenomatous polyposis coli; Gadd45a, growth arrest and DNA damage-inducible gene 45a; CK, casein kinase; PKA, protein kinase A; PKC, protein kinase C; wt, wild type; TCF, T-cell factor; PP2A, protein phosphatase 2A...
Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been associated with increased cell growth and proliferation both in normal and cancer cells. The ability of CK2 to also act as a potent suppressor of apoptosis offers an important link to its involvement in cance...
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practica
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In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) beta- subunit. Gene 298, 29-39.Jauch, E., J. Melzig, M. Brkulj, and T. Raabe. 2002 . In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) β-subunit. Gene 298: 29 – 39 ....
The highly conserved protein kinase casein kinase II (CKII) is required for efficient Pol III transcription of the tRNA and 5S rRNA genes in Saccharomyces cerevisiae. Using purified factors from wild-type cells to complement transcription extracts from a conditional lethal mutant of CKII we show ...
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