Milk proteins and milk protein-derived peptides have been widely studied for their health enhancing properties. This chapter presents the updated scientific knowledge on the bioactive properties of milk protein-derived peptides. The different bioactive p
We next investigated whether there is a difference in the genetic regulation of protein abundance between females and males by performing sex-biased protein quantitative trait locus (sb-pQTL) analysis in the dPFC, which is the brain region with the largest sample size with both genetic and proteom...
Mullighan and his colleagues make and test PROTACs and similar protein degraders for childhood blood cancers and brain tumours. As to whether protein degraders can cure these cancers, “there’s the potential”, says Mullighan. But he adds that one drug might not be enough. “Cancers are ...
What's the Treatment for High C-Reactive Protein? 2 min read Your body produces C-reactive protein, or CRP, when something is starting to become inflamed. So if a doctor finds CRP in your blood, which they can do through a test, they’ll know there’s inflammation happening somewhere in...
In these cases, a “protein group” (Fig. 1a) is formed, signifying either all or some subset of proteins in the group may be present in the sample. Fig. 1 Challenges of protein isoform identification using MS-based proteomics. a Many peptides detected in MS-based proteomics map to ...
However, MANF does not penetrate the blood–brain barrier. So far, MANF therapy has been administered by intracranial delivery, which is highly invasive and thus not a realistic approach for therapeutic use. Intranasal delivery of several other proteins is neuroprotective in rat and mouse transient...
hemoglobin or albumin adducts of xenobiotics are important dosimeters to monitor the presence of toxic metabolites in the human body (Fig.2). Stable blood protein adducts reflect the exposure history over a longer time period than do urinary metabolites, or than metabolites present in blood. Stable...
albicans EV protein markers including the claudin-like Sur7 family (Pfam: PF06687) proteins Sur7 and Evp1 (orf19.6741). A complementary set of 62 EV depleted proteins was selected as potential negative markers. Conclusions: The marker proteins for C. albicans EVs identified in this study will...
Leucine-Rich Glioma Inactivated protein 1 (LGI1) is a secreted neuronal protein highly expressed in the central nervous system and high amount are found in the hippocampus. An alteration of its function has been described in few families of patients with autosomal dominant temporal lobe epilepsy ...
Multinucleated osteoclasts, essential for skeletal remodeling in health and disease, are formed by the fusion of osteoclast precursors, where each fusion event raises their bone-resorbing activity. Here we show that the nuclear RNA chaperone, La protein has an additional function as an osteoclast fus...