The imprinted Grb10 gene encodes a signalling adaptor protein capable of inhibiting receptor tyrosine kinases, including the insulin receptor (Insr) and insulin-like growth factor type 1 receptor (Igf1r). Grb10 restricts fetal growth such that Grb10 knockout (KO) mice are at birth some 25-35...
inkeratinocytesisolated from plakoglobinknockout mice, the incorporation of desmosomal proteins such as desmogleins-1 and -2 into the plasma membrane was impaired (Yin et al., 2005a). This phenotype, which could not be rescued by β-catenin, was reversed by the reexpression of plakoglobin. In...
Proteinopathy in neurodegenerative diseases is typically characterized by deteriorating activity of specific protein aggregates. In tauopathies, including Alzheimer’s disease (AD), tau protein abnormally accumulates and induces dysfunction of the affect
Obesity is well-established as a significant contributor to the development of insulin resistance (IR) and diabetes, partially due to elevated plasma saturated free fatty acids like palmitic acid (PA). Grb10-interacting GYF Protein 2 (GIGYF2), an RNA-bin
Whether dysregulation of DNMT1 contributes to Naa10p mutation-caused developmental delays remains an intriguing question. To characterize the role of Naa10p in DNA methylation and development, we generated a Naa10p-knockout (KO) mouse model. Our results show that Naa10 KO leads to defects in ...
Genotype-phenotype association analysis between the a non-synonymousNESP55SNP and somatic cell count TheNESP55transcript is produced by the splicing of the firstNESPexon and GSα exons 2-13; however, the entireNESP55coding sequence is contained within its first exon with GSα exons 2-13 forming...
The level of inflammatory factors increasing with the progression of degeneration accelerates the degradation of aggrecan (AGC) and collagen (COL) as well as brings changes in the cell phenotype, providing a theoretical foundation for their clinical applications as potential therapeutic targets (C. Q....