Grb10 restricts fetal growth such that Grb10 knockout (KO) mice are at birth some 25-35% larger than wild type. Using a mouse genetic approach, we test the widely held assumption that Grb10 influences growth through interaction with Igf1r, which has a highly conserved growth promoting role...
The imprintedGrb10gene encodes a signalling adaptor protein capable of inhibiting receptor tyrosine kinases, including the insulin receptor (Insr) and insulin-like growth factor type 1 receptor (Igf1r).Grb10restricts fetal growth such thatGrb10knockout (KO) mice are at birth some 25-35% larger...
A low level of ALK expression is maintained in the adult brain and Alk knockout mice display a full lifespan [17]. Aberrant ALK activity has been strongly implicated in the oncogenesis of human cancer as a fusion protein in inflammatory myofibroblastic tumors, diffuse large B-cell lymphoma ...
Obesity is well-established as a significant contributor to the development of insulin resistance (IR) and diabetes, partially due to elevated plasma saturated free fatty acids like palmitic acid (PA). Grb10-interacting GYF Protein 2 (GIGYF2), an RNA-bin
Conversely, inhibition of TORC1 by rapamycin or S6K1 knockout prevented IGF-1-induced phosphorylation of BAD and blocked IGF-1-induced cell survival. Sign in to download full-size image Fig. 11.2. Cell survival function of TORC1. TORC1 activates S6K, which phosphorylates and inactivates pro-...
(Choi et al., 2009; Hatzfeld, 2007). Plakoglobin is critical for the early stages of desmosomal assembly. For example, inkeratinocytesisolated from plakoglobinknockout mice, the incorporation of desmosomal proteins such as desmogleins-1 and -2 into the plasma membrane was impaired (Yin et al...
In order to determine whether HP1α and/or HP1β isoforms have any role in stem cell pluripotency and early differentiation, we took advantage of the recently generated HP1α−/−and HP1β−/−knockout (KO) mice and of the derived pluripotent ESCs, the differentiated embryoid bodies ...
We also noticed that 40% of the Naa10-KO mice survived past 6 weeks but only had 80% of the body weight of their wild-type (WT) littermates at the age of 8 weeks. This reduced body weight persisted throughout development. At the age of 25 weeks, their body weight was only 75% ...
The phenotypic associations with SNP variation in theGNASdomain detected in this study are supported by genetic analysis of theGNASdomain in other mammalian species. Genetic defects within the humanGNASdomain can cause similar physiological defects to those observed in knockout mice strains. Heterozygous...
In CIRBP-knockout mice, bleeding associated with TNF-α release, inflammatory responses, and mortality were significantly reduced in the experimental animal model of sepsis and hemorrhagic shock (Qiang et al., 2013). CIRBP deficiency accelerated wound closure rates, resulting in the resolution of ...