Calcium signaling is essential for the release of neurotransmitters.37,38 For instance, dysregulation of the dopamine D1 receptor-mediated PLC/IP3/Ca2+ pathway in the anterior cortex of the brain is associated with mental illness in rats.39,40 PLC/IP3/Ca2+ pathway regulates the electrical ...
docking site” for growth factor receptor-bound protein 2(Grb-2) and its associated proteinson of sevenless(SOS). (2) The GrB-2–SOS complex activates Ras, the initiating signal in theMAPKpathway. LAT also activates phosphokinase Cγ1 (PKC), the initiating signal for the NF–κB pathway....
Fernandez-Sarabia, M. J., Sutton, A., Zhong, T., and Arndt, K. T., 1992, SIT4 protein phosphatase is required for the normal accumulation of SW14, CLN1, CLN2 and HCS26 RNAs during late G1,Genes Dev.6:2417–2428. PubMedCASGoogle Scholar Firmbach-Kraft, I., Byers, M., Shows...
The recently cloned Ash/Grb-2 protein, a 25-28 kDa molecule composed entirely of SH2 and SH3 domains, is a mammalian homolog of the Caenorhabditis elegans Sem-5 protein, which communicates between a receptor protein tyrosine kinase and a Ras protein. In the present study the function of ...
The category 1 protein tyrosine kinases are known as tyrosine receptor kinase or Trk (Patapoutian and Reichardt, 2001). Trks mediate the signaling systems of growth factors and neurotrophins and have been divided into three families: TrkA, TrkB, and TrkC. TrkA mediates the signaling of n...
(b) Cartoon illustrating the phosphorylated insulin receptor interacting region of the Grb14 protein from rat (PIR). PIR is the model intrinsically disordered protein used in this work. (c) Schematic representation of the length and sequence location of the three domains of Hmp. The specific RNC...
These phosphorylated substrates directly bind and activate enzymes such as phosphatidylinositol 3'-kinase (PI3K) and the guanine nucleotide exchange factor for p21Ras (GRB-2/SOS), which are in turn required for insulin-stimulated protein synthesis, cell cycle progression, and prevention of apoptosis....
Obesity is well-established as a significant contributor to the development of insulin resistance (IR) and diabetes, partially due to elevated plasma saturated free fatty acids like palmitic acid (PA). Grb10-interacting GYF Protein 2 (GIGYF2), an RNA-bin
The concurrent expression of the two cleavage products results in a high p38/Erk1/2MAPK activity ratio, which is critical for EC proliferation. Our findings identify a novel GrB-EHITSN-dependent pathogenic p38MAPK/Elk-1 signaling pathway involved in the poorly understood process of PL formation...
1. Objective To explore the mechanism of action of tanshinoneⅡA for liver protection in hepatic fibrotic mice by observing its effects on signaling pathway of insulin-like growth factor binding protein 7 (IGFBP7) and TGFβ1/Smad3. 目的通过观察胰岛素样生长因子结合蛋白7(IGFBP7)、转化生长因子-...