expression, subcellular localization, protein and genetic interactions, phylogeny, structure, sequence and functional assays)45. These predictions are displayed in the function prediction pages as GO MFO or BPO
This is an unavoidable limitation of the current prediction methods. A possible way that could be taken to address this issue is to extend the function prediction domain by bringing the functions of an ontology, such as GO, into the current functional domain. This extension could be done by ...
Precisely, a well-designed regularization is required to guarantee that all functional sites, discovered by HIGH-PPI, belong in the prepared domain database. The domain regularization and the PPI prediction loss form a flexible trade-off of learning objectives, which can appropriately tolerate the ...
Leveraging the underlying associations between the multiplicity of features that describe proteins could reveal functional insights into the diverse roles of proteins and improve performance on the automatic function prediction task. Results We present GO-LTR, a multi-view multi-label prediction model ...
protein functional domain名词解释protein functional domain名词解释 protein functional domain指的是蛋白质功能域。蛋白质功能域是蛋白质分子中能独立存在的功能单位。蛋白质功能域可以是一个蛋白质结构域,也可是由两个蛋白质结构域或两个以上的蛋白质结构域组成。
DOMpro: Protein Domain Prediction Using Profiles, Secondary Structure, Relative Solvent Accessibility, and Recursive Neural Networks 来自 掌桥科研 喜欢 0 阅读量: 79 作者:J Cheng,MJ Sweredoski,P Baldi 摘要: Protein domains are the structural and functional units of proteins. The ability to parse ...
Improving the performance of protein function prediction is the ultimate goal for a bioinformatician working in functional genomics. The classical prediction approach is to employ pairwise sequence alignments. However this method often f... A Al-Shahib,H Chao,AC Tan,... - Intelligent Data Engineer...
4.4.2Computational protein structure prediction Proteins are the structural and functional components of a cell. The functions of proteins are largely determined by their 3-D structures (sometimes called shapes or conformations). A protein may have multiple conformations. They undergo conformational change...
Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network PRODISTIN, a new computational method allowing the functional clustering of proteins on the basis of protein-protein interaction data. This method was used... C Brun,F Chevenet,D ...
For the convenience of discussion, in the following sections DCS (Domain Combination Similarity) will be adopted to calculate the current definition of f sim for protein function prediction. The pseudo code for calculating the functional similarity f sim (P A , P B ) between two proteins P A...