Chemical probes are selective small-molecule modulators, usually inhibitors, of their target protein’s function, that can be used in cell or even animal studies to interrogate the functions of their target pro
Here, we first describe the molecular mechanisms underlying the recruitment and function of PcG proteins in gene regulation during normal development. We then review the involvement of Polycomb complexes in cancer, highlighting PcG-dependent disturbances of epigenetic processes in tumorigenesis. Next, we ...
Here we demonstrate that the domain of unknown function 4005 (DUF4005) of the Arabidopsis IQD family protein ABS6/AtIQD16 is a novel MT-binding domain. Cosedimentation assays showed that the DUF4005 domain binds directly to MTs in vitro. GFP-labeled DUF4005 also decorates all types of MT...
(Thomas, Ayling, & Baneyx, 1997), prepared separately. The other is the use of the S30 extract prepared fromE. colicells overexpressing the molecular chaperones. The molecular chaperone sets DnaK/DnaJ/GrpE and GroEL/GroES are considered to function in the early and late stages of chaperone-...
3. You`d better know well the listed contents:the uppermost active site is peptidyl transferase enzyme catalytic site in ribosome; rRNA has important function in ribosome; there are a series of binding site and catalytic site which relate with synthesize of protein ...
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The core function of PDI-like protein members is to facilitate the formation of disulfide bonds for secretory and membrane proteins entering the SP, particularly in the ER [26,27,28,29]. This ensures that the client proteins are in a proper stabilization and maturation state prior to ER exit...
The other group -- the control group -- was put on a typical low-calorie diet with about 50 to 60 grams of protein a day. After six months, researchers found the high protein group had significantly improved their muscle function -- almost twice as much as the control group. "They ...
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产品活性:CHAC1 蛋白裂解谷胱甘肽,通过 ATF4-ATF3-DDIT3/CHOP 级联诱导细胞凋亡。它作为 Notch 信号通路的负调节因子,通过抑制 Notch 裂解来促进神经发生。CHAC1 蛋白, Human 是重组的 CHAC1 蛋白,由 E. coli 表达,带 C-Strep标签。CHAC1 蛋白, Human 全长 221 个氨基酸。 研究背景:CHAC1 是细胞过程中的关...