Chemical probes are selective small-molecule modulators, usually inhibitors, of their target protein’s function, that can be used in cell or even animal studies to interrogate the functions of their target proteins. Cheryl Arrowsmith, the leader of a new initiative called Target 2035, which seeks...
2023年7月14日，王磊研究员团队在Protein & Cell发表题为SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic的文章。该文章通过超分辨成像、细胞分级、蛋白质稳定性及表观修饰检测等多种手段论证了ORF8是一个内质网腔定位蛋白，不具有核定位和模拟组蛋白的功能，对ORF8调控宿主细胞表观遗传...
Here, we first describe the molecular mechanisms underlying the recruitment and function of PcG proteins in gene regulation during normal development. We then review the involvement of Polycomb complexes in cancer, highlighting PcG-dependent disturbances of epigenetic processes in tumorigenesis. Next, we ...
Here we demonstrate that the domain of unknown function 4005 (DUF4005) of the Arabidopsis IQD family protein ABS6/AtIQD16 is a novel MT-binding domain. Cosedimentation assays showed that the DUF4005 domain binds directly to MTs in vitro. GFP-labeled DUF4005 also decorates all types of MT...
(Thomas, Ayling, & Baneyx, 1997), prepared separately. The other is the use of the S30 extract prepared fromE. colicells overexpressing the molecular chaperones. The molecular chaperone sets DnaK/DnaJ/GrpE and GroEL/GroES are considered to function in the early and late stages of chaperone-...
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The core function of PDI-like protein members is to facilitate the formation of disulfide bonds for secretory and membrane proteins entering the SP, particularly in the ER [26,27,28,29]. This ensures that the client proteins are in a proper stabilization and maturation state prior to ER exit...
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is essential for brain function and depends on the intercellular protein-protein interactions of cell adhesion molecules (CAMs) at synaptic clefts. The CAM proteins link pre- and post-synaptic sites, and play essential roles in promoting synapse formation and maturation, maintaining synapse number and...
The ability to analyze protein function in a native context is central to understanding cellular physiology. This study explores whether tagging endogenous proteins with a reporter is a scalable strategy for generating cell models that accurately quantit