To determine whether the identified sex-specific causal proteins show sex-specific genetic risk, we asked whether the genetic interaction with sex in the corresponding GWAS was nominally significant for the considered trait for the sites that were most significantly associated with the trait at the lo...
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Although each laboratory establishes its own reference intervals based on their instrumentation, methodology, and patient population, in general, reference intervals for hemoglobin concentration are as follows: Men: 13.5–18.0 g/dL (135–180 g/L) Women: 12.0–15.0 g/dL (120–150 g/L) Newborns:...
In recent years, some PPIs modulators have entered clinical studies, some of which been approved for marketing, indicating that the modulators targeting PPIs have broad prospects. Here, we summarize the recent advances in PPIs modulators, including small molecules, peptides, and antibodies, hoping ...
Meaning The recommended dietary allowance for protein is sufficient to maintain lean body mass; protein intake exceeding the recommended dietary allowance does not increase lean body mass in functionally limited older men who are eating less than the recommended dietary allowance. Abstract Importance The...
Fig. 1. A–H: Bland–Altman plots of mean differences and limits of agreement between current or corrected bodyweight and FFM, stratified for BMI categories for men and female separately. In the participants with severe obesity, a notable underestimation of protein requirements in 26% is found,...
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H. Colloidal carriers for intravenous drug targeting: plasma protein adsorption patterns on surface‐modified latex particles evaluated by two‐dimensional polyacrylamide gel electrophoresis. Electrophoresis 14, 1382–1387 (1993). Article CAS Google Scholar Norman, M. E., Williams, P. & Illum, L. ...
PPIs are pivotal regulatory events in biological systems, providing the structural and functional basis for cellular processes, while abnormal PPIs have been extensively implicated in many human diseases5, 6, 7. For example, mixed-lineage leukemia (MLL) fusion proteins directly interact with menin ...